Chemical Properties:
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.Factory Supply Posaconazole Related Intermediates, Commercial Production Posaconazole CAS 171228-49-2 Posaconazole Intermediate POA CAS 149809-43-8 Phenyl (4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)carbamate CAS 184177-81-9 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine CAS 74853-08-0 2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxal CAS 170985-85-0 Diethyl L-(+)-Tartrate CAS 87-91-2| Item | Specifications |
| Appearance | Pale Brown to Off White Powder |
| Purity | ≥99.0% |
| Loss on Drying | ≤0.50% |
| Residue on Ignition | ≤0.20% |
| Single Impurity | ≤0.50% |
| Total Impurities | ≤1.0% |
| Heavy Metals (as Pb) | ≤20ppm |
| Residual Solvents | Meet the specifications |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Posaconazole (CAS 171228-49-2) |
Description:
Specifications:
Package & Storage:
| Chemical Name | 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine |
| Synonyms | 4-[4-(4-Aminophenyl)piperazin-1-yl]phenol |
| CAS Number | 74853-08-0 |
| CAT Number | RF-PI292 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C16H19N3O |
| Molecular Weight | 269.34 |
| Melting Point | >180℃(dec.) |
| Density | 1.237g/cm3 |
| Shipping Condition | Under Ambient Temperature |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine (CAS 74853-08-0) is the intermediate of Posaconazole (CAS 171228-49-2). Posaconazole is a triazole antifungal drug marketed in the United States by Schering-Plough under the trade name Noxafil. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase.
