Chemical Properties:
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture.Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Fmoc-O-(Benzylphospho)-L-Serine (Fmoc-Ser(HPO3Bzl)-OH) (CAS: 158171-14-3) with high quality. Ruifu Chemical supplys a series of amino acids. We can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Fmoc-Ser(HPO3Bzl)-OH, Please contact: alvin@ruifuchem.com| WGK Germany | 3 | HS Code | 2922491990 |
| F | 10-21 |
Description:
Safety Information:
Package & Storage:
| Chemical Name | Fmoc-O-(Benzylphospho)-L-Serine |
| Synonyms | Fmoc-Ser(HPO3Bzl)-OH; Fmoc-L-Ser(HPO3Bzl)-OH; Fmoc-Ser(PO(OBzl)OH)-OH; Fmoc-L-Ser(PO(OBzl)OH)-OH; Fmoc-O-(Benzylphospho)-L-Serine; Fmoc-O-Benzylphospho-L-Serine; Fmoc-O-Benzyl-L-Phosphoserine; O-Benzylphospho-N-Fmoc-L-Serine; N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-Benzyl-L-Phosphoserine |
| Stock Status | In Stock |
| CAS Number | 158171-14-3 |
| Molecular Formula | C25H24NO8P |
| Molecular Weight | 497.43 |
| Density | 1.403±0.06 g/cm3 |
| Water Solubility | Slightly Soluble in Water |
| Storage Temp. | Cool & Dry Place (2~8℃) |
| COA & MSDS | Available |
| Category | Fmoc-Amino Acids |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White to Off-White Powder | White Powder |
| Specific Rotation [α]20/D | -12.0° to -14.0° (C=1, DMF) | -13.1° |
| TLC | ≥98.0% | >98.0% |
| Element Analysis (C、H、N) | ≤5.0% | <5.0% |
| Loss on Drying | <0.50% | 0.23% |
| Clarity of Solution | 0.3 gram in 2ml DMF Clear Solution | Complies |
| AcOH | <0.50% (HPLC) | 0.101% |
| Purity / Analysis Method | >98.0% (HPLC) | 98.68% |
| Infrared Spectrum | Conforms to Structure | Complies |
| Proton NMR Spectrum | Conforms to Structure | Complies |
| Conclusion | The product has been tested & complies with the specifications | |
Application:
Fmoc-O-(Benzylphospho)-L-Serine (Fmoc-Ser(HPO3Bzl)-OH) (CAS: 158171-14-3) is a serine derivative, building block for the synthesis of phosphoserine containing peptides, phospho amino acids for phosphopeptides. Fmoc-Ser(HPO3Bzl)-OH can be applied in the synthesis of phosphopeptides. This derivative can be introduced using standard activation methods, such as PyBOP and TBTU. The monoprotected phosphoserine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods. β-piperidinylalanine formation has been shown to occur during Fmoc deprotection of N-terminal Ser(PO(OBzl)OH), particularly under microwave conditions. This side reaction can be eliminated by using cyclohexylamine or DBU just for this Fmoc deprotection step. Fmoc-Ser(HPO3Bzl)-OH is a monobenzyl protected phospho amino acid that significantly improved the synthesis of phosphorpeptides with higher yields and purities. Phosphopeptides are widely employed in cell signaling and also can work as self antigens which may induce positive immune responses.