Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureRuifu Chemical Supply Telmisartan Intermediates With High Purity Telmisartan CAS 144701-48-4 Methyl 2-(p-Tolyl)benzoate CAS 114772-34-8 2-(p-Tolyl)benzoic Acid CAS 7148-03-0 Telmisartan Benzimidazole Acid CAS 152628-03-0 Telmisartan Methyl Ester CAS 528560-93-2 Methyl 2-[4-(Bromomethyl)phenyl]benzoate CAS 114772-38-2 Methyl 4-(Butyrylamino)-3-Methyl-5-Nitrobenzoate CAS 152628-01-8 2-n-Propyl-4-Methyl-6-(1-Methylbenzimidazole-2-yl)benzimidazole CAS 152628-02-9| Item | Specifications |
| Appearance | White or Off-White Crystalline Powder |
| Odor | Characteristic |
| Solubility | Sparingly Soluble in Methylene Chloride, Slightly Souble in Methanol, Parctically Insoluble in Water, Disolves in 1M Solution Hydroxide |
| IR Identification | Should Correspond to the RS Infrared Absorption |
| HPLC Identification | Retention Time of Major Peak Should Correspond to RS |
| Purity / Analysis Method | >99.5% (HPLC) |
| Loss on Drying | <1.00% |
| Residue on Ignition | <0.10% |
| Related Substances | |
| Telmisartan Related Compound A | <0.10% |
| Telmisartan Amide | <0.10% |
| Telmisartan Related Compound B | <0.10% |
| Telmisartan Diacide | <0.10% |
| Telmisartan Tert-Butyl Ester | <0.20% |
| Telmisartan Unknown Impurity | <0.20% |
| Unspecified Impurity | <0.10% |
| Total Impurities | <1.00% |
| Residual Solvents | |
| Methanol | <0.30% |
| Ethanol | <0.50% |
| Methylene Dichloride | <0.06% |
| n-Hexane | <0.029% |
| Acetic Acid Ethyl Ester | <0.50% |
| Toluene | <0.089% |
| Acetic Acid | <0.50% |
| Heavy Metals | <10ppm |
| Arsenic (As) | <1.00ppm |
| Lead (Pb) | <1.00ppm |
| Cadmium (Cd) | <1.00ppm |
| Particle Size | D90 Not More Than 15μm |
| Bulk Density (g/cc) | 0.11~0.20 |
| Tapped Density (g/cc) | 0.22~0.30 |
| Residual Pesticide | Negative |
| Total Plate Count | <1000cfu/g |
| Yeast & Mold | <100cfu/g |
| E. Coli | Negative |
| Salmonella | Negative |
| Test Standard | Enterprise Standard; USP 41 Standard |
| Usage | API |
Description:
Specifications:
Package & Storage:
| Chemical Name | Telmisartan |
| Synonyms | 4'-[[4-Methyl-6-(1-Methyl-1H-Benzimidazol-2-yl)-2-Propyl-1H-Benzimidazol-1-yl]methyl]biphenyl-2-Carboxylic Acid; 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-Benzimidazol]-1'-yl)methyl]-[1,1'-Biphenyl]-2-Carboxylic Acid |
| CAS Number | 144701-48-4 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C33H30N4O2 |
| Molecular Weight | 514.63 |
| Melting Point | 261.0~263.0℃ |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
Telmisartan (CAS: 144701-48-4) is a benzimidazole derivative and a non-peptide angiotensin II receptor antagonist with antihypertensive property. Telmisartan selectively antagonizes angiotensin II binding to the AT1 subtype receptor, located in vascular smooth muscle and adrenal gland. The antagonism results in vasodilation and inhibits the angiotensin II-mediated aldosterone production, which in turn leading to a decrease in sodium and water as well as an increase in potassium excretion leading to a subsequent reduction in blood pressure. Telmisartan is a new type of blood pressure drugs, is used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Telmisartan was originally formulated by the German pharmaceutical company Boehringer Ingelheim; it earned the German patent EP502,314 in 1991, was first approved to enter the American market in November 1998, and then entered German, Philippines, Australian, Belgium, British, and other markets.
