Chemical Properties:
Package: Bottle, Cardboard Drum, 25kg/Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.Commercial Supply Palonosetron Hydrochloride and Related Intermediates: (S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS: 85977-52-2 (R)-1,2,3,4-Tetrahedro-1-Naphthoic Acid CAS: 23357-47-3 (S)-3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4 3-Quinuclidinone Hydrochloride CAS: 1193-65-3 1-Naphthoic Acid CAS: 86-55-5 Palonosetron Hydrochloride CAS: 135729-62-3 API| Item | Specifications |
| Appearance | White or Almost White Crystalline Powder |
| Chemical Purity | ≥99.0% |
| Enantimoer Excess | e.e. ≥99.0% |
| Isomer Impurity | ≤1.0% |
| Loss on Drying | ≤0.50% |
| Relate Substance | ≤1.0% |
| Moisture (K.F) | ≤1.0% |
| Specific Rotation [α]D20 | -59.0°~ -63.0°(C=0.3 in Benzence) |
| Heavy Metals | ≤20ppm |
| Storage | 5-8℃ Airtightness |
| Test Standard | Enterprise Standard |
| Usage | Palonosetron Hydrochloride (CAS: 135729-62-3) Intermediates |
Description:
Specifications:
Package & Storage:
| Chemical Name | (S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid |
| Synonyms | (1S)-1,2,3,4-Tetrahydronaphthalene-1-Carboxylic acid |
| CAS Number | 85977-52-2 |
| CAT Number | RF-CC111 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C11H12O2 |
| Molecular Weight | 176.21 |
| Density | 1.186g/cm3 |
| Melting Point | 54.0~56.0℃ |
| Boiling Point | 342.7°C at 760 mmHg |
| Refractive Index | 1.576 |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid (CAS: 85977-52-2) with high quality. It is an intermediate typically in the synthesis of Palonosetron Hydrochloride (CAS: 135729-62-3). Palonosetron Hydrochloride (CAS: 135729-62-3) is a novel 5-HT3 receptor antagonist launched as an injectable agent for the prevention of acute and delayed nausea and vomiting associated with cancer chemotherapy. It has a much longer half-life (~40 h) than the other currently available 5-HT3 antagonists, which provides efficacy advantages in the prevention of delayed nausea and vomiting that typically occurs after 24 h and up to six days post chemotherapy administration. With 1,2,3,4-tetrahydro-1-Naphthoic Acid as the starting material, the split, amination, reduction, cyclization, salt of palonosetron hydrochloride granisetron.
