Chemical Properties:
Package: Fluorinated Bottle, 25kg/bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of S-(Carboxymethyl)-L-Cysteine (Carbocisteine) (CAS: 638-23-3) with high quality. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in S-(Carboxymethyl)-L-Cysteine, Please contact: alvin@ruifuchem.com| Hazard Codes | Xi - Irritant | RTECS | AY4342000 |
| Risk Statements | 36/37/38 | TSCA | Yes |
| Safety Statements | 24/25-36-26 | HS Code | 2930909099 |
| WGK Germany | 2 | Toxicity | LD50 oral in rat: > 15gm/kg |
Description:
Safety Information:
Package & Storage:
| Chemical Name | S-(Carboxymethyl)-L-Cysteine |
| Synonyms | Carbocysteine; Carbocisteine; S-Carboxymethyl-L-Cysteine; 3-[(Carboxymethyl)thio]alanine; 3-Carboxymethylthio-L-Alanine; L-Cys(carboxymethyl)-OH; (R)-2-Amino-3-(Carboxymethylthio)propionic Acid; (L)-2-Amino-3-(Carboxymethylthio)propionic Acid; (2R)-2-Amino-3-[(Carboxymethyl)thio]propionic Acid; S-(Carboxymethyl)-(R)-Cysteine |
| Stock Status | In Stock |
| CAS Number | 638-23-3 |
| Molecular Formula | C5H9NO4S |
| Molecular Weight | 179.19 |
| Melting Point | 208.0~213.0℃(dec.) |
| Solubility in Hot Water | Almost Transparency |
| Solubility | Very Slight Soluble in Water, Practically Insoluble in Ethanol and in Glacial Acetic Acid and in Ether. Dissolves in Dilute Hydrochloric Acid and in Sodium Hydroxide T.S.. |
| Storage Temp. | Sealed in Dry, Store at Room Temperature |
| COA & MSDS | Available |
| Classification | Amino Acids & Derivatives |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White Crystals or Crystalline Powder | Conforms |
| Identification | Infrared Absorption Spectrum | Conforms |
| Specific Rotation [α]20/D | -33.5° to -36.5° | -33.8° |
| State of Solution (Transmittance) | Clear and Colorless ≥98.0% | 98.3% |
| Chloride (Cl) | ≤0.039% | <0.039% |
| Sulfate (SO4) | ≤0.020% | <0.020% |
| Ammonium (NH4) | ≤0.020% | <0.020% |
| Iron (Fe) | ≤30ppm | <30ppm |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Arsenic (As2O3) | ≤1.0ppm | <1.0ppm |
| Ninhydrin-Positive Substances | Meets the Requirements | Conforms |
| Other Amino Acids | Chromatographically Not Detectable | Conforms |
| Loss on Drying | ≤0.30% | 0.24% |
| Residue on Ignition (Sulfated) | ≤0.10% | 0.09% |
| Assay | 98.5 to 101.0% | 99.7% |
| pH Value | 2.0 to 3.5 | 2.7 |
| Conclusion | This Product by Inspection Accords with the Standard of AJI97 | |
Application:
S-(Carboxymethyl)-L-Cysteine (Carbocisteine; Carbocysteine) (CAS: 638-23-3), is a mucolytic that reduces the viscosity of sputum and so can be used to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis by allowing the sufferer to bring up sputum more easily. Carbocisteine should not be used with antitussives (cough suppressants) or medicines that dry up bronchial secretions. Carbocisteine is produced by alkylation of cysteine with chloroacetic acid. It is an important pharmaceutical raw material; used in the synthesis of a variety of drugs, can reduce the stickiness of respiratory secretions, for the treatment of chronic tracheitis, emphysema, tuberculosis and so on. Used in biochemical research, as a phlegm solubilizer. Use phlegm dissolving medicine, occasionally mild dizziness, nausea, stomach upset, diarrhea, gastrointestinal bleeding, skin rash and other adverse reactions. Use with caution in patients with digestive tract. This product is a mucolytic agent, an expectorant, and an anti-nasal infection drug. It is mainly used for the treatment of diseases such as thick sputum, difficulty in expectoration and obstruction of sputum and trachea caused by diseases such as chronic bronchitis and bronchial asthma Carbocisteine is a mucus thinner, its effect is similar to that of bromhexine. It mainly affects the secretion of bronchial glands at the cellular level. It can break the disulfide bond of mucin in the mucus and make low-viscosity sialo mucin. The secretion is increased, and the production of high-viscosity fucomucin is reduced, so that the viscosity of sputum is reduced, which is conducive to the discharge of sputum. The oral administration takes effect quickly, and the obvious effect can be seen within 4 hours after taking it. It is widely distributed in the lung tissues, and finally excreted in the urine in the form of prototypes and metabolites.638-23-3 AJI97 Test Method:
S-(Carboxymethyl)-L-Cysteine, when dried, contains not less than 98.5 percent and not more than 101.0 percent of S-(Carboxymethyl)-L-Cysteine (C5H9NO4S). Description: White crystals or crystalline powder, slightly acid taste. Very slight soluble in water, practically insoluble in ethanol and in glacial acetic acid and in ether. Dissolves in dilute hydrochloric acid and in sodium hydroxide T.S.. Solubility (H2O, g/100g): 0.13 (20℃) Identification: Compare the infrared absorption spectrum of the sample with that of the standard by potassium bromide disc method. Specific Rotation [α]20/D: Dried sample, C=10, pH6.0. After drying the sample, take about 5g of the sample. accurately weighed, dissolve in 20ml of water and sodium hydroxide solution (13→100). After pH adjust to 6.0 with 1mol/L or 0.1mol/L hydrochloric acid T.S., then add water to accurately 50ml. State of Solution (Transmittance): 1.0g in 10ml of 1mol/L NaOH, spectrophotometer, 430nm, 10mm cell thickness. Chloride (Cl): 0.36g, A-2, ref: 0.40ml of 0.01mol/L HCl Ammonium (NH4): A-1 Sulfate (SO4): 1.2g, (2), ref: 0.50ml of 0.005mol/L H2SO4 Iron (Fe): 0.5g, (2), ref: 1.5ml of Iron Std. (0.01mg/ml) Heavy Metals (Pb): 2.0g, (2), ref: 2.0ml of Pb Std. (0.01mg/ml) Arsenic (As2O3): 2.0g, (3), ref: 2.0ml of As2O3 Std. Other Amino Acids: 0.2mol/L NaOH, test Sample: 75μg, B-2-a control; S-(Carboxymethyl)-L-Cysteine 0.15μg. After each of the solutions is spotted on the plate, the plate is developed at once Loss on Drying: at 105℃ for 3 hours Residue on Ignition (Sulfated): AJI Test 13 Assay: Dried sample, 180mg, 0.1mol/L HCLO4 1ml=17.920mg C5H9NO4S. Dissolve about 180mg of the sample, previously dried and accurately weighed, in 3ml of formic acid, add exactly 15ml of 0.1mol/L perchloric acid, and 50ml of glacial acetic acid, and titrate the excess perchloric acid with 0.1mol/L sodium acetate, determing the endpoint potentiometrically. Perform a blank determination, and make necessary correction. Each ml of 0.1mol/L perchloric acid is equivalent to 17.920mg of C5H9NO4S. pH: 1.0g in 10ml (Saturated aqueous solution) Recommended storage limit and condition: Preseved tight containers at controlled room temperature (2 years).