Chemical Properties:
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.Manufacturer with High Purity and Stable Quality Chemical Name: Rapamycin; Sirolimus; RAPA CAS: 53123-88-9 Macrolide Immunosuppressive Agent API High Quality, Commercial Production| Item | Specifications |
| Appearance | White or Off-White Crystalline Powder |
| Identification A | The IR spectrum of potassium bromide preparation of the sample exhibits maxima at the same wavelengths as that of a similar preparation of in-house reference standard |
| Identification B | The UV spectrum of 95% ethanol preparation of the sample exhibits maxima at 267nm, 277nm, 288nm as that of a similar preparation of in-house reference standard |
| Identification C | The retention time of the peaks for the trans-and cis-stereoisomers in the chromatogram of assay preparation corresponds to that in the chromatogram of the standard preparation,as obtained in the assay |
| Optical Rotation | -147.0°~ -157.0° |
| Loss on Drying | ≤0.50% |
| Residue on Ignition | ≤0.20% |
| Heavy Metals | ≤20ppm |
| Individual Impurity | ≤1.5% |
| Total Impurities | ≤2.0% (excluding Cis-Stereoisomer of Sirolimus) |
| Cis-Stereoisomer of Sirolimus | ≤5.0% |
| Residual Solvents | |
| Ethanol | ≤5000ppm |
| Ethyl Acetate | ≤5000ppm |
| Cyclohexane | ≤5000ppm |
| Acetone | ≤5000ppm |
| Diethyl Ether | ≤5000ppm |
| Assay | ≥98.5% (Calculated trans- and cis-stereoisomer of sirolimus on the dired basis) |
| Test Standard | Chinese Pharmacopoeia (CP); Enterprise Standard |
| Usage | Active Pharmaceutical Ingredient (API) |
Description:
Specifications:
Package & Storage:
| Chemical Name | Rapamycin |
| Synonyms | Sirolimus; RAPA; AY-22989 |
| CAS Number | 53123-88-9 |
| CAT Number | RF-API59 |
| Stock Status | In Stock, Production Scale Up to Hundreds of Kilograms |
| Molecular Formula | C51H79NO13 |
| Molecular Weight | 914.19 |
| Melting Point | 183.0~185.0℃ |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
Rapamycin (Sirolimus; AY 22989) is is an autophagy activator, a new form of macrolide immunosuppressive agent with good curative effects, low toxicity, and no nephrotoxicity. It can be used to maintain the immunity of transplant organs (especially in kidney transplants) to alleviate immunological rejections after organ transplant surgeries.
