Chemical Properties:
Package: Bottle, Aluminum foil bag, 25kg/Cardboard Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureLeading Manufacturer and Supplier, Intermediates of Ramelteon Ramelteon (TAK-375) CAS 196597-26-9 2,3-Dihydrobenzofuran CAS 496-16-2 1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-one CAS 196597-78-1 Ramelteon Acrylonitrile CAS 196597-79-2 Despropionyl Ramelteon Hydrochloride CAS 196597-80-5 2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6 Please contact: alvin@ruifuchem.com| Item | Specifications |
| Appearance | White to Pale Yellow Solid Powder |
| Purity / Analysis Method | >98.5% (HPLC) |
| Melting Point | 133.0 to 137.0℃ |
| Water (by Karl Fischer) | <0.50% |
| Residue on Ignition | <0.10% |
| Total Impurities | <1.50% |
| 1 H NMR Spectrum | Consistent With Structure |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Ramelteon (CAS: 196597-26-9) |
Description:
Specifications:
Package & Storage:
| Chemical Name | 1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one |
| Synonyms | 6,7-Dihydro-1H-Indeno[5,4-b]furan-8(2H)-one; Ramelteon Intermediate 1; Ramelteon I |
| Impurity | Ramelteon Impurity A |
| CAS Number | 196597-78-1 |
| CAT Number | RF2883 |
| Stock Status | In Stock, Production Capacity 20 Tons per Month |
| Molecular Formula | C11H10O2 |
| Molecular Weight | 174.20 |
| Melting Point | 133.0 to 137.0℃ |
| Boiling Point | 334.2±42.0℃ |
| Density | 1.288±0.06 g/cm3 |
| Hazard Class | Irritant |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Application:
1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one (CAS: 196597-78-1) is used as an intermediate of Ramelteon (CAS: 196597-26-9), the mother nucleus of synthesizing Ramelteon. Ramelteon is the first in a new class of sleep agents that selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN), instead of binding to GABA receptors. Ramelteon does not show any appreciable binding to GABAA receptors, which are associated with anxiolytic, myorelaxant, and amnesic effects. Ramelteon can be used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse, and the withdrawal and rebound insomnia that is typical with GABA modulators is not present in ramelteon. Some clinicians also use ramelteon for the treatment of Delayed sleep phase syndrome. Treating insomnia (trouble falling asleep). It may also be used for other conditions as determined by your doctor. Ramelteon is a melatonin agonist. It works by acting on the melatonin receptors in the brain, which helps you fall asleep.Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available