Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry (≤-20℃) warehouse away from incompatible substances. Protect from light and moisture. Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of PyAOP (CAS: 156311-83-0) with high quality. Ruifu supplys a series of protecting reagents and coupling reagents. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase PyAOP, Please contact: alvin@ruifuchem.comDescription:
Package/Storage/Shipping:
| Chemical Name | PyAOP |
| Synonyms | (7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium Hexafluorophosphate; ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium Hexafluorophosphate(V); (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-Pyrrolidinylphosphonium Hexafluorophosphate |
| Stock Status | In Stock, Mass Production |
| CAS Number | 156311-83-0 |
| Molecular Formula | C17H27F6N7OP2 |
| Molecular Weight | 521.38 g/mol |
| Melting Point | 158.0~168.0℃(lit.) |
| Density | 1.276 |
| Water Solubility | Soluble in Water |
| Storage Temp. | Cool & Dry Place (≤-20℃), Protect from Light |
| COA & MSDS | Available |
| Category | Coupling Reagents |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White to Off-White Crystalline Powder | Complies |
| Melting Point | 158.0~168.0℃ | 160.4~162.8℃ |
| Loss on Drying | <0.50% | 0.13% |
| Purity / Analysis Method | >99.0% (HPLC) | 99.7% |
| Infrared Spectrum | Conforms to Structure | Complies |
| 1 H NMR Spectrum | Conforms to Structure | Complies |
| Solubility in CHCL3 | Colorless, Clear, 25mg/ml | Pass |
| PF6 | (Gravimetric Analysis With Tetraphenylarsonium Chloride) | 26.8~28.8% |
| Conclusion | The product has been tested & complies with the given specifications | |
156311-83-0 - Risk and Safety:
Application:
Hazard Symbols Xi - Irritant Risk Codes 36/37/38 - Irritating to eyes, respiratory system and skin. Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. WGK Germany 3 RTECS TH3890000 HS Code 2933990099(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium Hexafluorophosphate (PyAOP) (CAS: 156311-83-0) is used as a coupling reagent in solid phase peptide synthesis. It is preferred over HATU, because it does not side react at the N-terminus of the peptide. Compared to the HOBt derivates, PyAOP (and HOAt in general) are more reactive due to the additional nitrogen. PyAOP is a phosphonium salt used as a coupling reagent in solid-phase peptide synthesis, without undergoing side reactions with the amino terminus. PyAOP is a derivative of HOAt. PyAOP is a phosphonium salt derivative from HOAt used a peptide coupling reagent. PyAOP is stable as a solid and in DMF solution, effective in solid-phase and solution-based peptide synthesis, successful with sterically hindered amino acids, in the formation of cyclic peptides and in the solid-phase synthesis of fluorescently labelled peptides. PyAOP achieves excellent yields at good reaction rates and suppresses racemisation. PyAOP is the pyrrolidino analogue of AOP and was designed with the aim of generating a less-toxic by-product than HMPA, which is produced with AOP. Reagent for synthesis of: Cyclic RGC pentapeptides for functionalization through click chemistry; Fluorescent glucose bioprobes; ReactIR™ flow cell Reagent for: Disulfide bond engineering; Heteroaryl ether synthesis; Optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.