Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.Manufacturer Supply With High Quality, Commercial Production Chemical Name: 2-Cyanophenylboronic Acid 1,3-Propanediol Ester CAS: 172732-52-4| Item | Specifications |
| Appearance | White to Light Yellow Powder to Crystal |
| Purity / Analysis Method | >99.0% (HPLC) |
| Loss on Drying | <0.50% |
| Residue on Ignition | <0.20% |
| Single Impurity | <0.50% |
| Total Impurities | <1.00% |
| Heavy Metals (as Pb) | <20ppm |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Perampanel (CAS: 380917-97-5) |
Description:
Specifications:
Package & Storage:
| Chemical Name | 2-Cyanophenylboronic Acid 1,3-Propanediol Ester |
| Synonyms | 2-Cyanobenzeneboronic Acid 1,3-Propanediol Ester; 2-(1,3,2-Dioxaborinan-2-yl)benzonitrile |
| CAS Number | 172732-52-4 |
| CAT Number | RF-PI1350 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C10H10BNO2 |
| Molecular Weight | 187.01 |
| Melting Point | 46.0~51.0℃ (lit.) |
| Solubility | Soluble in Methanol |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) is used in the synthesis of Perampanel (CAS: 380917-97-5), an AMPA receptor antagonist. Perampanel (licensed in 2012) is a third- generation AED known with the proprietary brand name of Fycompa® (Eisai, Hatfield) in the UK and Banzel® (Eisai, Hatfield) in the USA. In October 2012, the US FDA approved perampanel for the treatment of partial onset seizures in epileptic patients who are at least 12 years old. Perampanel is the first AMPA receptor antagonist to receive FDA approval as an AED. AMPA glutamate receptors are found primarily on postsynaptic neurons in the brain. As a selective, noncompetitive antagonist of AMPA, parampanel prevents ion channel opening and reduces propagation of action potential.
