Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture. Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Pentafluorophenol (CAS: 771-61-9) with high quality, mass production. Ruifu Chemical can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Pentafluorophenol, Please contact: alvin@ruifuchem.com| Item | Specifications |
| Appearance | White Low Melting Point Crystal Solid |
| Purity / Analysis Method | ≥99.0% (HPLC) |
| Melting Point | 34.0~36.0℃ |
| Water by Karl Fischer | ≤0.50% |
| Residue on Ignition | ≤0.20% |
| Single Impurity | ≤0.50% |
| Total Impurities | ≤1.00% |
| Heavy Metals | ≤20ppm |
| Infrared Spectrum | Conforms to Structure |
| Proton NMR Spectrum | Conforms to Structure |
| Test Standard | Enterprise Standard |
| Attention | Protect from the light and store in a cool and dry place (2~8℃) |
| Note | This product is low melting point solid, may change state in different environments (solid, liquid or semi-solid) |
Description:
Specifications:
Package & Storage:
| Name | Pentafluorophenol |
| Synonyms | 2,3,4,5,6-Pentafluorophenol; Perfluorophenol; PFP; PFP-OH |
| CAS Number | 771-61-9 |
| Stock Status | In Stock, Mass Production |
| Molecular Formula | C6HF5O |
| Molecular Weight | 184.07 |
| Condition to Avoid | Air Sensitive |
| Melting Point | 34.0~36.0℃(lit.) |
| Boiling Point | 143℃(lit.) |
| Density | 1.757 |
| Solubility in Water | Slightly Soluble in Water |
| COA & MSDS | Available |
| Category | Coupling Reagents |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
771-61-9 - Risk and Safety:
Risk Codes R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R63 - Possible risk of harm to the unborn child R43 - May cause sensitization by skin contact R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R45 - May cause cancer R67 - Vapors may cause drowsiness and dizziness R40 - Limited evidence of a carcinogenic effect Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. S23 - Do not breathe vapour. S53 - Avoid exposure - obtain special instructions before use. UN IDs 2811 WGK Germany 3 RTECS SM6680000 FLUKA BRAND F CODES 3 TSCA T HS Code 2908199090 Hazard Note Toxic/Irritant Hazard Class 8 Packing Group III Toxicity LD50 scu-rat: 322 mg/kg IZSBAI 3,91,65
Application:
Pentafluorophenol (CAS: 771-61-9) can be used for the preparation of penta-fluorophenyl esters for peptide synthesis. It is used in the preparation of pentafluorophenyl esters for peptide synthesis and vulcanized polymers. It is also used for peptide coupling and heterocyclic acid derivatives. It is involved in the preparation of pentafluorophenyl formate which acts as a formulating agent for amines and amino acids. It can be used for synthesizing novel reagents which can achieve highly diastereoselective acetal cleavage. Pentafluorophenol is also the intermediate of Sofosbuvir in the treatment of Hepatitis C Virus (HCV). Pentafluorophenol is a polyfluoro liquid crystal compound with small steric hindrance, which is an important intermediate for the preparation of high performance liquid crystal materials, it is especially suitable for the preparation of polyfluoro monomer liquid crystal materials. After the polyfluoro monomer liquid crystal materials are mixed with low viscosity and high dielectric anisotropy nematic liquid crystal materials, the dipole distance of molecules can be increased, reducing the response time, improving the display performance of the liquid crystal material, increasing the clarity, has an important meaning to the production of high performance liquid crystal materials. Pentafluorophenol is an important intermediate, mainly used in the preparation of pharmaceutical, liquid crystal and polymer materials intermediates, such, in the field of medicine and pesticide, pentafluorophenol is used to prepare pentafluorophenyl active ester for peptide synthesis, thus promoting the formation of peptide, pentafluorophenyl ester can be used for solid phase synthesis of peptides, it can also be used for liquid phase synthesis, and can also be used as a protecting group for an amino acid protecting group alkyl ester or sulfonic acid group.