Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureRuifu Chemical Supply Palbociclib Related Intermediates: Palbociclib CAS 571190-30-2 5-Bromo-2,4-Dichloropyrimidine CAS 36082-50-5 5-Bromo-2-Chloro-N-Cyclopentylpyrimidin-4-Amine CAS 733039-20-8 tert-Butyl 4-(6-Nitropyridin-3-yl)piperazine-1-Carboxylate CAS 571189-16-7 tert-Butyl 4-(6-Amino-3-Pyridyl)piperazine-1-Carboxylate CAS 571188-59-5 6-Bromo-2-Chloro-8-Cyclopentyl-5-Methylpyrido-[2,3-d]pyrimidin-7(8H)-one CAS 1016636-76-2 2-Chloro-8-Cyclopentyl-5-Methyl-8H-Pyrido[2,3-d]pyrimidin-7-one CAS 1013916-37-4| Item | Specifications |
| Appearance | White to Light Yellow Powder |
| Purity / Analysis Method | >99.0% (HPLC) |
| Related Substances | <1.00% |
| Loss on Drying | <0.50% |
| Water (K.F) | <0.50% |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Palbociclib (CAS: 571190-30-2) |
Description:
Specifications:
Package & Storage:
| Chemical Name | 6-Bromo-2-Chloro-8-Cyclopentyl-5-Methylpyrido-[2,3-d]pyrimidin-7(8H)-one |
| Synonyms | Palbociclib-Pb3 |
| CAS Number | 1016636-76-2 |
| CAT Number | RF-PI1849 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C13H13BrClN3O |
| Molecular Weight | 342.63 |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one (CAS: 1016636-76-2) is an intermediate of Palbociclib (CAS: 571190-30-2). Palbociclib is a drug for the treatment of ER-positive and HER2-negative breast cancer developed. Palbociclib is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. On February 3, 2015, the US FDA approved Pfizer's Palbociclib (trade name: Ibrance) for the treatment of advanced/metastatic breast cancer in postmenopausal women. Palbociclib is the first CDK4/6 inhibitor to receive FDA approval.
