Chemical Properties:
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of N-Acetyl-L-Cysteine (Ac-Cys-OH; NAC) (CAS: 616-91-1) with high quality. Ruifu Chemical supplys a series of amino acids and derivatives. Because of our excellent product quality, reasonable prices, we gained good reputation as well as trust from our at home and abroad customers. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in N-Acetyl-L-Cysteine, Please contact: alvin@ruifuchem.com| Risk Statements | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Statements | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | HA1660000 |
| F | 10-23 |
| TSCA | Yes |
| HS Code | 2922491990 |
Description:
Safety Information:
| Chemical Name | N-Acetyl-L-Cysteine |
| Synonyms | Ac-Cys-OH; Acetylcysteine; NAC; LNAC; N-Acetylcysteine; N-Acetyl-3-Mercaptoalanine; Acetyl-Laevo-Cysteine |
| Stock Status | In Stock, Production Capacity 50 Tons per Month |
| CAS Number | 616-91-1 |
| Molecular Formula | C5H9NO3S |
| Molecular Weight | 163.19 |
| Melting Point | 106.0~108.0℃(lit.) |
| Sensitive | Air Sensitive |
| Water Solubility | Soluble in Water, Almost Transparency |
| Solubility | Soluble in Ethanol, Methanol, Alcohol. Practically Insoluble in Ether |
| Storage Temp. | Sealed in Dry, Store at Room Temperature |
| COA & MSDS | Available |
| Classification | Amino Acids & Derivatives |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White Crystals or Crystalline Powder; Strongly Acid Taste | Conforms |
| Identification | Infrared Absorption Spectrum | Conforms |
| Specific Rotation [α]20/D | +21.3° to +27.0° (C=5 in Phosphate Buffered Saline) | +23.5° |
| State of Solution (Transmittance) | Clear and Colorless ≥98.0% | 99.0% |
| Chloride (Cl) | ≤0.040% | <0.040% |
| Sulfate (SO4) | ≤0.030% | <0.030% |
| Ammonium (NH4) | ≤0.020% | <0.020% |
| Iron (Fe) | ≤20ppm | <20ppm |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Zinc (Zn) | ≤10ppm | <10ppm |
| Arsenic (As2O3) | ≤1.0ppm | <1.0ppm |
| Related Substances | (HPLC Method) | |
| L-Cystine | ≤0.50% | Conforms |
| L-Cysteine | ≤0.50% | Conforms |
| N,N'-Diacetyl-L-Cystine | ≤0.50% | Conforms |
| N,S-Diacetyl-L-Cysteine | ≤0.50% | Conforms |
| Each Other Impurity | ≤0.50% | Conforms |
| Total Impurities | ≤0.50% | Conforms |
| Loss on Drying | ≤0.50% | 0.20% |
| Residue on Ignition (Sulfated) | ≤0.20% | 0.05% |
| Assay | 98.5 to 101.0% (on the Dried Basis) | 99.90% |
| pH Value | 2.0 to 2.8 (1.0g in 100ml of H2O) | 2.5 |
| Biochemical Toxicity | Passes | Passes |
| Volatile Organic Substances | Pass | Pass |
| Endonuclease Detection | ≤0.1 EU/g | <0.1 EU/g |
| Conclusion | Accords with the Standard of AJI97; USP35 | |
Application:
Function & Application of N-Acetyl-L-Cysteine (Ac-Cys-OH; NAC) (CAS: 616-91-1) powder 1. N-Acetyl-L-Cysteine, also known as N-Acetylcysteine or Acetylcysteine (NAC), is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Other uses include sulfate repletion in conditions, such as autism, where cysteine and related sulfur amino acids may be depleted. 2. N-Acetyl-L-Cysteine is a derivative of cysteine where an acetyl group is attached to the nitrogen atom. This compound is sold as a dietary supplement commonly claiming antioxidant and liver protecting effects. It is used as a cough medicine because it breaks disulfide bonds in mucus and liquefies it, making it easier to cough up. It is also this action of breaking disulfide bonds that makes it useful in thinning the abnormally thick mucus in cystic and pulmonary fibrosis patients. 3. Acetylcysteine is a mucolytic agent with strong mucolytic effect. The sulfhydryl group contained in the molecule can break the disulfide bond in the glycoprotein polypeptide chain in the sputum, thereby reducing the viscosity of the sputum, and making the sputum liquid and easy to cough up. This product can also break DNA fibers in purulent sputum, so it can not only dissolve white sticky sputum, but also purulent sputum. For patients whose general expectorants are ineffective, this product can still be effective. 4. It is used as a medicine to dissolve phlegm. It is used in biochemical research and medicine as an antidote for phlegm and acetaminophen poisoning. Biochemical reagent, medicine, this product is used as expectorant, said that phlegm is easy to clean. 5. Common side effects include nausea and vomiting when taken by mouth.The skin may occasionally become red and itchy with either form. A non-immune type of anaphylaxis may also occur. It appears to be safe in pregnancy. For paracetamol overdose, it works by increasing the level of glutathione, an antioxidant that can neutralise the toxic breakdown products of paracetamol. When inhaled, it acts as a mucolytic by decreasing the thickness of mucus. 6. Acetylcysteine was initially patented in 1960 and came into medical use in 1968. It is on the World Health Organization's List of Essential Medicines, which lists the safest and most effective medicines needed in a health system. It is available as a generic medication and is inexpensive. 7. N-Acetyl-L-Cysteine is the acetylated form of L-cysteine which is more efficiently absorbed and used. It is also an antioxidant that is helpful against viruses. N-Acetyl-l-Cysteine has been used as a liver protectant and to break up pulmonary and bronchial mucus. 8. N-Acetyl-L-Cysteine can boost glutathione levels in cells. 9. N-Acetyl-L-Cysteine is a conditionally essential amino acid, one of only three sulfur-containing amino acids, the others being taurine (which can be produced from L-cysteine) and L-methionine from which L-cysteine can be produced in the body by a multi-step process. 10. N-Acetyl-L-Cysteine can act as an antioxidant, may prevent liver diseases, and can help to thicken the individual diameters of existing hair if taken regularly. 11. Application in medical fields As Respiratory system agent, it can be used as medicine for dissolving phlegm drums. it can cure bronchitis. moreover, N-Acetyl-L-Cysteine can used as antidote when acetaminophen poisoning. 12. Application in cosmetic fields N-Acetyl-L-Cysteine have a great effect in clearing oxygen free radicals and other oxides and slowing the aging process, it also can disturb the melanin production, and is helpful to eliminate the freckle on the skin 13. Application in animal feed N-Acetyl-L-Cysteine can be used as feed additive. 14. Cosmetics mainly used for beauty water, perm fluid, sun-proof skin care cream. Has a function to prevent biological aging. N-Acetyl-l-Cysteine can effectively prevent and treat radiation injury. N-acetyl Cysteine can remove the skin melanin itself, change the nature of the skin itself, the skin becomes natural whitening.It is a kind of ideal natural whitening cosmetics. 15. Food additive. Used in bread, to promote the formation of gluten and promote fermentation, mold, prevent aging. Used in natural juices to prevent vitamin C from oxidizing and to prevent the juices from turning brown.Process Flow Chart of N-Acetyl-L-Cysteine:
AJI97 / USP35 Test Method:
N-Acetyl-L-Cysteine (Ac-Cys-OH; NAC) (CAS: 616-91-1) AJI97 Test Method N-Acetyl-L-Cysteine, when dried, contains not less than 98.5 percent and not more than 101.0 percent of N-Acetyl-L-Cysteine (C5H9NO3S ). Description: White crystals or crystalline powder, strongly acid taste. Freely soluble in water, soluble in ethanol, practically insoluble in ether. Solubility (H2O, g/100g): 17 (20℃), 80 (40℃), 260 (60℃) Identification: Compare the infrared absorption spectrum of the sample with that of the standard by potassium bromide disc method. Specific Rotation [α]20/D: Dried sample, C=8, phosphate buffer solution State of Solution (Transmittance): 0.5g in 10ml of H2O, spectrophotometer, 430nm, 10mm cell thickness. Heavy Metals (Pb): 2.0g, (1), ref: 2.0ml of Pb Std. (0.01mg/ml) Zinc (Zn): Atomic absorption method Related Substances: HPLC method Loss on Drying: In vacuum, at 70℃ for 4 hours Residue on Ignition (Sulfated): AJI Test 13 Assay: Dried sample, 200mg, 0.05mol/L I2 1ml=16.320mg C5H9NO3S pH: 1.0g in 100ml of H2O Recommended storage limit and condition: Preseved tight containers at controlled room temperature (1 years). N-Acetyl-L-Cysteine (Ac-Cys-OH; NAC) (CAS: 616-91-1) USP35 Test Method DEFINITION Acetylcysteine contains NLT 98.0% and NMT 102.0% of L-threonine (C5H9NO3S), calculated on the dried basis. IDENTIFICATION A. INFRARED ABSORPTION <197K> ASSAY PROCEDURE Mobile phase: 6.8 g/L of monobasic potassium phosphate. Adjust with phosphoric acid to a pH of 3.0. Sodium metabisulfite solution: 0.5 mg/mL of sodium metabisulfite in water, freshly prepared Internal standard solution: 5 mg/mL of USP L-Phenylalanine RS in Sodium metabisulfite solution Standard stock solution: 10 mg/mL of USP Acetylcysteine RS in Sodium metabisulfite solution Standard solution: 0.5 mg/mL of USP Acetylcysteine RS and 0.25 mg/mL of USP L-Phenylalanine RS in Sodium metabisulfite solution from Standard stock solution and Internal standard solution Sample stock solution: 10 mg/mL of Acetylcysteine in Sodium metabisulfite solution Sample solution: 0.5 mg/mL of Acetylcysteine and 0.25mg/mL of USP L-Phenylalanine RS in Sodium metabisulfite solution from Sample stock solution and Internal standard solution Chromatographic system (See Chromatography <621>, System Suitability.) Mode: LC Detector: UV 214 nm Column: 3.9-mm × 30-cm; packing L1 Flow rate: 1.5 mL/min Injection size: 5 µL System suitability [NOTE-The relative retention times for acetylcysteine and L-phenylalanine are about 0.5 and 1.0, respectively.] Suitability requirements Resolution: NLT 6 between acetylcysteine and L-phenylalanine Relative standard deviation: NMT 2.0% Analysis Samples: Standard solution and Sample solution Calculate the percentage of acetylcysteine (C5H9NO3S) in the portion of Acetylcysteine taken: Result = (RU/RS) × (CS/CU) × 100 RU = peak response ratio of acetylcysteine to L-phenylalanine from the Sample solution RS = peak response ratio of acetylcysteine to L-phenylalanine from the Standard solution CS = concentration of USP Acetylcysteine RS in the Standard solution (mg/mL) CU = concentration of acetylcysteine in the Sample solution (mg/mL) Acceptance criteria: 98.0%-102.0% on the dried basis IMPURITIES RESIDUE ON IGNITION <281>: NMT 0.5% HEAVY METALS, Method II <231> [CAUTION-Exercise care because explosion may occur.] Analysis: In a dropwise manner, wet the sample with 2 mL of nitric acid, and proceed as directed for the Test preparation. Acceptance criteria: NMT 10 ppm SPECIFIC TESTS OPTICAL ROTATION, Specific Rotation <781S> Buffer: Mix 29.5 mL of 1 N sodium hydroxide, 50 mL of 1 M monobasic potassium phosphate, and sufficient water to make 100 mL. Adjust to a pH of 7.0 ± 0.1 by adding more of either solution, as necessary. Sample solution: In a 25-mL volumetric flask, mix 1.25 g with 1 mL of edetate disodium solution (1 in 100), add 7.5mL of sodium hydroxide solution (1 in 25), and mix to dissolve. Dilute with Buffer to volume. Acceptance criteria: +21° to +27° pH <791>: 2.0-2.8 in a solution (1 in 100) LOSS ON DRYING <731>: Dry a sample at a pressure of about 50 mm of mer cury at 70° for 4 h: it loses NMT 1.0% of its weight. ADDITIONAL REQUIREMENTS PACKAGING AND STORAGE: Preserve in tight containers, and store at controlled room temperature. USP REFERENCE STANDARDS <11> USP Acetylcysteine RS USP L-Phenylalanine RSPackage & Storage:
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.