L-(+)-Lysine Monohydrochloride CAS 657-27-2 (H-Lys-OH·HCl) Assay 98.5~101.0% Factory High Quality

Chemical Name: L-(+)-Lysine Monohydrochloride Synonyms: H-Lys-OH·HCl; L-Lysine Hydrochloride  CAS: 657-27-2 Assay: 98.5~101.0%   Appearance: White Crystals or Crystalline Powder  Amino Acid, Capacity 1000 Tons per Year, High Quality Contact: Dr. Alvin Huang Mobile/Wechat/WhatsApp: +86-15026746401 E-Mail: alvin@ruifuchem.com

Products Details

Chemical Properties:

Package: Fluorinated Bottle, 25kg/bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture. Keep away from strong oxidizing agents.Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of L-(+)-Lysine Monohydrochloride (H-Lys-OH·HCl) (CAS: 657-27-2) with high quality, production capacity 1000 Tons per year. As one of the largest amino acids suppliers in China, Ruifu Chemical supplys amino acids up to international standards, such as AJI, USP, EP, JP and FCC standards. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in L-(+)-Lysine Monohydrochloride, Please contact: alvin@ruifuchem.com
Risk Codes 34 - Causes burns
Safety Description S24/25 - Avoid contact with skin and eyes.   
UN IDs UN 1789 8/PG 3
WGK Germany  2
HS Code              2922419000 

Description:

Safety Information:

Package & Storage:

Chemical Name L-(+)-Lysine Monohydrochloride 
Synonyms H-Lys-OH·HCl; L-Lysine Monohydrochloride; L-Lysine Hydrochloride; L-Lysine HCl; Laevo-Lysine Hydrochloride; Lysine Hydrochloride; Lysine Monohydrochloride; (S)-2,6-Diaminohexanoic Acid Monohydrochloride
Stock Status In Stock, Production Capacity 1000 Tons per Year 
CAS Number 657-27-2 
Molecular Formula C6H14N2O2·HCl 
Molecular Weight 182.65  
Melting Point 263℃(dec.)(lit.)
Density 1.28 g/cm3 (20℃)
Water Solubility  Soluble in Water, Almost Transparency
Solubility  Freely Soluble in Water and Formic Acid. Very Slightly Soluble in Ethanol. Practically Insouble in Ether
Storage Temp.  Sealed in Dry, Store at Room Temperature
COA & MSDS Available
Classification Amino Acid and Derivatives
Brand Ruifu Chemical

Advantages:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com  15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality AssuranceStrict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. SamplesMost products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory AuditFactory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. TransportationBy Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom SynthesisCan provide custom synthesis services to best fit your research needs. Payment TermsProforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc. 

FAQ:

Stable Supply: Maintain reasonable stock    

Professional Service: One stop purchasing service

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

Fast Delivery: If within stock, three days delivery guaranteed

High Quality: Established a complete quality assurance system

Sufficient Capacity: Sufficient facilities and technicians

OEM Package: Custom package and label available

Specifications:

Items Inspection Standards Results
Appearance White Crystals or Crystalline Powder Conforms          
Identification Infrared Absorption Spectrum Conforms
Specific Rotation [α]20/D +20.4° to +21.4°(C=8 in 6N HCl) +20.8°
State of Solution (Transmittance) Clear and Colorless ≥98.0% 98.8%
Chloride (Cl) 19.0 to 19.6% 19.15%
Sulfate (SO4) ≤0.020% <0.020%
Ammonium (NH4) ≤0.020% <0.020%
Iron (Fe) ≤10ppm <10ppm
Heavy Metals (Pb) ≤10ppm <10ppm 
Arsenic (As2O3) ≤1.0ppm <1.0ppm
Other Amino Acids ≤0.50% (TLC) Conforms
Loss on Drying ≤0.40% (at 105℃ for 3 hours) 0.25%
Residue on Ignition (Sulfated) ≤0.10% 0.06%
Assay 98.5 to 101.5% (as Dry Basis)  99.7%
Organic Volatile Impurities Meet the Requirement Conforms
pH Test  5.0 to 6.0 (1.0g in 10ml of H2O) 5.2
Residual Solvents Conforms Conforms
Conclusion Meets with the Standard of AJI97; USP; JP
Shelf Life 24 Months From Manufacture Date if Stored Properly 
Main Uses Amino Acids; Food / Feed Additives; Pharmaceutical; Nutritional Enhancer; etc.

Application:

L-(+)-Lysine Monohydrochloride (H-Lys-OH·HCl) (CAS: 657-27-2) is widely used as nutritional supplements in food and beverage industries. It can also be used in animal feed as source of L-Lysine. L-Lysine Monohydrochloride can be used in a wide variety of industries including: food production, beverage, pharmaceutical, agriculture/animal feed, and various other industries. Product Functions & Applications: 1. Lysine HCL is a feed nutrition fortifier, which has the functions of enhancing appetite of livestock and poultry, improving disease resistance, promoting wound healing, improving meat quality, enhancing gastric secretion, and synthesizing brain nerves, germ cells, proteins and hemoglobin essential substances. Generally the amount added in the feed is 0.1-0.2%. 2. Lysine HCL is an essential amino acid in the human body, which can enhance hematopoietic function, enhance gastric juice secretion, increase protein utilization, increase disease resistance, maintain metabolic balance, and help promote the development of children's chemicalbook physical and mental development. China stipulates that flour, biscuits and bread that can be used for processing noodles are used in an amount of 1 to 2g/kg; 0.3 to 0.8g/kg in drinking liquid. 3. Lysine HCL is one of the most important amino acids, and the amino acid industry has now become an industry of considerable scale and importance. Lysine is mainly used in food, medicine and feed. Function: 1. Food grade: nutritional enhancer, used for seasoning in mayonnaise, milk, instant noodles food  2. Medcine grade: preparation for compound amino acid transfusion, improving efficiency of drugs  3. Feed grade: make poultry nutrition balance, improve meat quality and productivity  L-(+)-Lysine Monohydrochloride is mainly produced by fermentation using strains of corynebacteria, especially Corynebacterium glutamicum, which comprises a multi-step process including fermentation, cell separation by centrifugation or ultrafiltration, product separation and purification, evaporation and drying. Because of L-Lysine great importance, efforts are constantly being made in order to improve the fermentation processes, comprising strain and process development as well as media optimization and downstream processing are used for the production of L-lysine and other L-amino acids, operation in mixing tank or air lift fermenters.  

AJI97 / USP35 / JP17 Test Methods:

L-(+)-Lysine Monohydrochloride (CAS: 657-27-2) AJI 97 Test Method Identification: Compare the infrared absorption spectrum of the sample with that of the standard by potassium bromide disc method. Specific Rotation [α]20/D: Dried Sample, C=8, 6mol/L HCl State of Solution (Transmittance): 1.0g in 10ml of H2O spectrophotometer, 430nm, 10nm cell thickness. Chloride (Cl): Dried Sample, 370mg, B-1 Ammonium (NH4): B-1 Sulfate (SO4): 1.2g, (1), ref: 0.50ml of 0.005mol/L H2SO4 Iron (Fe): 1.5g, (1), ref: 1.5ml of Iron Std. (0.01mg/ml) Heavy Metals (Pb): 2.0g, (4), ref: 2.0ml of Pb Std. (0.01mg/ml) Arsenic (As2O3): 2.0g, (1), ref: 2.0ml of As2O3 Std. Other Amino Acids: Test Sample: 50μg, S-6-a, control: L-Lys HCl 0.25μg Loss on Drying: at 105℃ for 3 hours. Assay: Dried sample, 110mg, (3), 2ml of formic acid, 0.1mol/L HCLO4 1ml=9.133mg C6H14N2O2·HCl pH Test: 1.0g in 10ml of H2O L-(+)-Lysine Monohydrochloride (CAS: 657-27-2) USP35 Test Method DEFINITION Lysine Hydrochloride contains NLT 98.5% and NMT 101.5% of L-Lysine Hydrochloride (C6H14N2O2·HCl), calculated on the dried basis. IDENTIFICATION A. INFRARED ABSORPTION <197K> ASSAY PROCEDURE Sample: 90 mg of Lysine Hydrochloride Blank: Mix 3 mL of formic acid and 50 mL of glacial acetic acid. Titrimetric system (See Titrimetry <541>) Mode: Direct titration Titrant: 0.1 N perchloric acid VS Endpoint detection: Potentiometric Analysis: Dissolve the Sample in 3 mL of formic acid and 50mL of glacial acetic acid. Add 10 mL of mercuric acetate TS, and titrate with the Titrant. Perform the Blank determination. Calculate the percentage of Lysine Hydrochloride (C6H14N2O2·HCl) in the Sample taken: Result = {[(VS-VB) xNxF]/W} x100 VS= Titrant volume consumed by the Sample (mL) VB= Titrant volume consumed by the Blank (mL) N= actual normality of the Titrant (mEq/mL) F= equivalency factor, 91.33 mg/mEq W= Sample weight (mg) Acceptance criteria: 98.5%~101.5% on the dried basis OTHER COMPONENTS CONTENT OF CHLORIDE Sample: 350 mg of Lysine Hydrochloride Blank: 140 mL of water Titrimetric system (See Titrimetry <541>) Mode: Direct titration Titrant: 0.1 N silver nitrate VS Endpoint detection: Visual Analysis: Transfer the Sample to a porcelain casserole, and add 140 mL of water and 1 mL of dichlorofluorescein TS. Titrate with the Titrant until the silver chloride flocculates and the mixture acquires a faint pink color. Perform the Blank determination. Calculate the percentage of chloride (Cl) in the Sample taken: Result = {[(VS − VB) × N × F]/W} × 100 VS = Titrant volume consumed by the Sample (mL) VB = Titrant volume consumed by the Blank (mL) N = actual normality of the Titrant (mEq/mL) F = equivalency factor, 35.45 mg/mEq W = Sample weight (mg) Acceptance criteria: 19.0%~19.6% IMPURITIES RESIDUE ON IGNITION <281>: NMT 0.1% CHLORIDE AND SULFATE, Sulfate <221> Standard solution: 0.10mL of 0.020 N sulfuric acid Sample: 0.33g of Lysine Hydrochloride Acceptance criteria: NMT 0.03% IRON <241>: NMT 30ppm Delete the following: HEAVY METALS, Method I <231>: NMT 15ppm RELATED COMPOUNDS Standard solution: 0.05 mg/mL of USP L-Lysine Hydrochloride RS in water. [NOTE-This solution has a concentration equivalent to 0.5% of that of the Sample solution.] Sample solution: 10mg/mL of Lysine Hydrochloride in water System suitability solution: 0.4 mg/mL each of USP L-Lysine Hydrochloride RS and USP Arginine Hydrochloride RS Chromatographic system (See Chromatography <621>, Thin-Layer Chromatography.) Mode: TLC Adsorbent: 0.25-mm layer of chromatographic silica gel mixture Application volume: 5μL Developing solvent system: Isopropyl alcohol and ammonium hydroxide (7:3) Spray reagent: 0.2 g of ninhydrin in a mixture of butyl alcohol and 2N acetic acid (95:5) System suitability Suitability requirements: The chromatogram of the System suitability solution exhibits two clearly separated spots. Analysis Samples: Standard solution, System suitability solution, and Sample solution. Dry the plate between 100° and 105° until the ammonia completely disappears. Spray with Spray reagent, and heat between 100° and 105° for 15 min. Examine the plate under white light. Acceptance criteria: Any secondary spot of the Sample solution is not larger or more intense than the principal spot of the Standard solution. Individual impurities: NMT 0.5% Total impurities: NMT 2.0% SPECIFIC TESTS OPTICAL ROTATION, Specific Rotation <781S> Sample solution: 80 mg/mL in 6 N hydrochloric acid Acceptance criteria: +20.4° to +21.4° LOSSON DRYING <731>: Dry a sample at 105℃ for 3 h: it loses NMT 0.4% of its weight. ADDITIONAL REQUIREMENTS PACKAGING AND STORAGE: Preserve in well-closed containers. USP REFERENCE STANDARDS <11> USP Arginine Hydrochloride RS USP L-Lysine Hydrochloride RS  L-(+)-Lysine Monohydrochloride (CAS: 657-27-2) JP17 Test Method  L-Lysine Hydrochloride, when dried, contains not less than 98.5% of L-lysine hydrochloride (C6H14N2O2.HCl). DescriptionL-Lysine Hydrochloride occurs as a white powder. It has a slight, characteristic taste. It is freely soluble in water and in formic acid, and practically insoluble in ethanol (95). It shows crystal polymorphism. Identification (1) Determine the infrared absorption spectrum of L-Lysine Hydrochloride, previously dried, as directed in the potassium bromide disk method under Infrared Spectrophotometry <2.25>, and compare the spectrum with the Reference Spectrum: both spectra exhibit similar intensities of absorption at the same wave numbers. If any difference appears between the spectra, dissolve L-Lysine Hydrochloride in water, evaporate the water to dryness at 60℃, and repeat the test with the residue. (2) A solution of L-Lysine Hydrochloride (1 in 10) responds to the Qualitative Tests <1.09> for chloride. Optical rotation <2.49>[α]20/D: +19.0 - +21.5° (after drying, 2 g, 6 mol/L hydrochloric acid TS, 25 mL, 100 mm) pH <2.54> Dissolve 1.0 g of L-Lysine Hydrochloride in 10 mL of water: the pH of this solution is between 5.0 and 6.0. Purity (1) Clarity and color of solution-Dissolve 1.0 g of L-Lysine Hydrochloride in 10 mL of water: the solution is clear and colorless. (2) Sulfate <1.14>-Perform the test with 0.6 g of L-Lysine Hydrochloride. Prepare the control solution with 0.35 mL of 0.005 mol/L sulfuric acid VS (not more than 0.028%). (3) Ammonium <1.02>-Perform the test with 0.25 g of L-Lysine Hydrochloride. Prepare the control solution with 5.0 mL of Standard Ammonium Solution (not more than 0.02%). (4) Heavy metals <1.07>-Proceed with 2.0 g of L-Lysine Hydrochloride according to Method 1, and perform the test. Prepare the control solution with 2.0 mL of Standard Lead Solution (not more than 10 ppm). (5) Arsenic <1.11>-Prepare the test solution with 1.0 g of L-Lysine Hydrochloride according to Method 1, and perform the test (not more than 2 ppm). (6) Related substances-Dissolve 0.10 g of L-Lysine Hydrochloride in 25 mL of water, and use this solution as the sample solution. Pipet 1 mL of the sample solution, add water to make exactly 50 mL, pipet 5 mL of this solution, add water to make exactly 20 mL, and use this solution as the standard solution. Perform the test with these solutions as directed under Thin-layer Chromatography <2.03>. Spot 5μL each of the sample solution and standard solution on a plate of silica gel for thin-layer chromatography. Develop the plate with a mixture of 1-propanol and ammonia water (28) (67:33) to a distance of about 10 cm, and dry the plate at 100℃ for 30 minutes. Spray evenly the plate with a solution of ninhydrin in acetone (1 in 50) and heat at 80℃ for 5 minutes: the spots other than the principal spot from the sample solution are not more intense than the spot from the standard solution. Loss on drying <2.41> Not more than 1.0% (1 g, 105℃, 3 hours). Residue on ignition <2.44> Not more than 0.1% (1 g). Assay Weigh accurately about 0.1 g of L-Lysine Hydrochloride, previously dried, dissolve in 2 mL of formic acid, add exactly 15 mL of 0.1 mol/L perchloric acid VS, and heat on a water bath for 30 minutes. After cooling, add 45 mL of acetic acid (100), and titrate <2.50> the excess perchloric acid with 0.1 mol/L sodium acetate VS (potentiometric titration). Perform a blank determination, and make any necessary correction. Each mL of 0.1 mol/L perchloric acid VS =9.132 mg of C6H14N2O2.HCl Containers and storage Containers-Tight containers.

Contact us

Please feel free to give your inquiry in the form below We will reply you in 24 hours