Chemical Properties:
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of L-Leucine Methyl Ester Hydrochloride (H-Leu-OMe·HCl) (CAS: 7517-19-3) with high quality. Ruifu Chemical supplys amino acids and derivatives, can provide worldwide delivery, small and bulk quantities available. If you need it, Please contact: alvin@ruifuchem.com| Hazard Codes | Xi | WGK Germany | 3 |
| Risk Statements | 36/37/38 | Hazard Class | IRRITANT |
| Safety Statements | 22-24/25-36/37/39-27-26 | HS Code | 2922491990 |
| WGK Germany | 3 |
Description:
Safety Information:
Package & Storage:
| Chemical Name | L-Leucine Methyl Ester Hydrochloride |
| Synonyms | H-Leu-OMe·HCl; L-Leu-OMe·HCl; L-Leucine Methyl Ester HCl; Methyl L-Leucinate Hydrochloride; (S)-2-Amino-4-Methyl-Pentanoic Acid Methyl Ester Hydrochloride; (S)-Leucine Methyl Ester Hydrochloride; Leucine Methyl Ester Hydrochloride; Methyl (S)-2-Amino-4-Methylpentanoate Hydrochloride; Methyl (S)-Leucinate Hydrochloride |
| Stock Status | In Stock, Production Capacity 30 Tons per Month |
| CAS Number | 7517-19-3 |
| Molecular Formula | C7H15NO2·HCl |
| Molecular Weight | 181.66 |
| Melting Point | 148.0~150.0℃ |
| Sensitive | Hygroscopic |
| Water Solubility | Soluble in Water |
| Storage Temp. | Room Temperature |
| Shipping | Normal |
| COA & MSDS | Available |
| Classification | Amino Acids and Derivatives |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White or Off-White Microcrystalline Powder | Conforms |
| Specific Rotation [α]20/D | +12.0° to +14.0°(C=2 in H2O) | +13.0° |
| Melting Point | 148.0~150.0℃ | 148.0~150.0℃ |
| 300 MHz 1H-NMR spectrum | Consistent With the Standard | Consistent |
| TLC Analysis | One Spot | Conforms |
| Loss on Drying | <0.50% | 0.21% |
| Sulfate Ash | <0.20% | 0.11% |
| D-Enantiomer | <0.50% | Conforms |
| Substances Not Precipitated by Ammonia | <0.50% | Conforms |
| Assay | >99.0% | 99.2% |
| Solubility in Water | Clear or Slightly Hazy (50mg/ml) | Conforms |
| Conclusion | This Product by Inspection Accords with the Enterprise Standard | |
| Main Uses | Amino Acids and Derivatives; Pharmaceutical Intermediates | |
Application:
L-Leucine Methyl Ester Hydrochloride (H-Leu-OMe·HCl) (CAS: 7517-19-3) is a leucine derivative, is used for biochemical reagents, pharmaceutical intermediates. Amino acids and amino acid derivatives have been commercially used as pharmaceutical intermediates in the pharmaceutical industry, people have pay more and more attention to amino acids.Test Method:
1. Appearance Take an appropriate amount of this product, put it on smooth white paper and spread 5 cm2 and 5 mm thick. Observe it in a bright place. 2. Purity (HPLC) 2.1 Instrument High performance liquid chromatography, PDA detector. Electronic analytical balance 2.2 Reagents Acetonitrile (chromatographic grade), TFA(chromatographic grade) 2.3 Chromatographic conditions 2.3.1 Column: YMC-ODS-AM, 5 μl, 150 x 4.6 mm 2.3.2 Detection wavelength: INC220nm Flow rate: 1.0mL/min Injection volume:10 μL (for reference) Diluent: Acetonitrile Run time: 20 minutes 2.4 Mobile phase preparation Mobile phase A (0.1% trifluoroacetic acid water): accurately absorbing 2.0ml TFA, Dilute to 2000ml with water, mix and degas; Mobile phase B (0.1% trifluoroacetic acid acetonitrile ): accurately absorbing 2.0ml TFA, Dilute to 2000ml with acetonitrile, mix and degas; 2.5 Instrumental parameters Time (min) A% B% 0.00 90 10 12.00 10 90 15.00 10 90 15.01 90 10 20.00 90 10 2.6 Preparation of sample solution Weigh and dissolve 0.1g sample with acetonitrile, dilute to 100ml, shake well for use, or the same concentration. Prepare two samples in parallel. 2.7 Sample Determination Analyze the sample according to the following sampling procedure: More than 1 injection of blank solution 1 needle sample solution 1# 1 needle sample solution 2# 2.8 Result Calculation 2.8.1 The peak area normalization method was used to calculate the HPLC purity by deducting blank space. 2.8.2 The relative mean deviation of the purity of two needles shall not be greater than 1% 2.8.3 If the results of both injections meet the acceptance criteria, the average purity is taken as the final result. 3, Melting point -- RY-1 melting point instrument 4. Loss on drying test method 4.1 Instruments: Electric thermostatic drying oven, 1/10,000 balance. 4.2 Procedure: In a flat weighing bottle with a constant weight and over-drying ground mouth cover, weigh 1 gram (accurate to 0.0001 gram) of the sample. The sample should be evenly spread at the bottom of the weighing bottle with a thickness of no more than 10mm, put in a thermostatic electric drying oven, dry at 105~110℃ for 3 hours, and then move into the drying room to cool to room temperature for weighing. Calculation: Loss on drying %= (M1-M2) ÷M×100 Where: M1: weight of sample and measuring bottle before drying, grams M2: weight of sample and measuring bottle after drying, in grams M: Sample weight, grams 5. Specific rotation -- Specific rotation is measured in accordance with GB/T613-1988 Sample preparation: 1.0000g sample was accurately weighed and moved to a clean and dry 50ml volumetric bottle, 20ml water was added, the bottle was capped and shaken to dissolve, and then diluted to the scale with water. Test: Adjust the zero of the gyroscope before the test, then load the test tube with the sample solution, record the rotation Angle, and calculate the specific rotation of the sample with the following formula. [а]D20 = (r×50) ÷ (L×W) [а]D20: Specific optical rotation at 20℃ of sample solution r: Optical rotation observed at 20℃ for the sample solution 50: Volume of prepared sample solution (ml) w: Sample weight (g) L: Optical rotation tube length (dm)