Chemical Properties:
L-Cysteine Hydrochloride Monohydrate (CAS: 7048-04-6) AJI97 Test Method Identification: Compare the infrared absorption spectrum of the sample with that of the standard by potassium bromide disc method. Specific Rotation [α]D20: Dried sample, C=8, 1mol/L HCl State of Solution (Transmittance): 1.0g in 10ml of H2O, spectrophotometer, 430nm, 10mm cell thickness. Chloride (Cl): 350mg, B-2 Ammonium (NH4): A-1 Sulfate (SO4): 1.2g, (1), ref: 0.50ml of 0.005mol/L H2SO4 Iron (Fe): 1.5g, ref: 1.5ml of Iron Std. (0.01mg/ml) Heavy Metals (Pb): 2.0g, (1), pH=7, ref: 2.0ml of Pb Std. (0.01mg/ml) Arsenic (As2O3): 2.0g, (1), ref: 2.0ml of As2O3 Std. Other Amino Acids: Test Sample: 50μg, B-6-a, control; L-Cys·HCl·H2O 0.25μg Loss on Drying: In vacuum, P2O5, at room temperature for 20 hours. Residue on Ignition (Sulfated): AJI Test 13 Assay: Dried sample, 250mg, 0.05mol/L I2 1ml=15.762mg C3H7NO2S·HCl pH Test: 1.0g in 100ml of H2O L-Cysteine Hydrochloride Monohydrate (CAS: 7048-04-6) USP35 Test Method DEFINITION Cysteine Hydrochloride is L-Cysteine Hydrochloride Monohydrate and contains NLT 98.5% and NMT 101.5% of L-Cysteine Hydrochloride (C3H7NO2S·HCl), calculated on the dried basis. IDENTIFICATION A. INFRARED ABSORPTION <197K> ASSAY PROCEDURE Sample: 250 mg of Cysteine Hydrochloride Blank: Proceed as directed in the Analysis without the Sample. Titrimetric system (See Titrimetry <541>) Mode: Residual titration Titrant: 0.1 N iodine VS Back titrant: 0.1 N sodium thiosulfate VS Endpoint detection: Visual Analysis: Transfer the Sample to an iodine flask. Add 20.0 mL of water and 4 g of potassium iodide, and mix. Cool the solution in an ice bath, and add 5 mL of 3 N hydrochloric acid and 25.0 mL of 0.1 N iodine VS. Insert the stopper, and allow to stand in the dark for 20 min. Titrate the excess iodine with the Back titrant. Add 3 mL of star ch TS as the endpoint is approached. Per form the Blank determination. Calculate the percentage of cysteine hydrochloride (C3H7NO2S·HCl) in the Sample taken: Result = {[(VB − VS) × N × F]/W} × 100 VB = Back titrant volume consumed by the Blank (mL) VS = Back titrant volume consumed by the Sample (mL) N = actual normality of the Back titrant (mEq/mL) F= equivalency factor, 157.6 mg/mEq W= Sample weight (mg) Acceptance criteria: 98.5%~101.5% on the dried basis IMPURITIES RESIDUEON ON IGNITION <281>: NMT 0.4% CHLORIDE AND SULFATE, Sulfate <221> Standard solution: 0.10 mL of 0.020 N sulfuric acid Sample: 0.33 g of Cysteine Hydrochloride Acceptance criteria: NMT 0.03% IRON <241>: NMT 30ppm HEAVY METALS, Method I <231>: NMT 15ppm RELATED COMPOUNDS N-Ethylmaleimide solution: 40 mg/mL of N-ethylmaleimide in alcohol Standard stock solution: Dissolve 20 mg of USP L-Cysteine Hydrochloride RS in 10.0 mL of water. Add 10.0 mL of N-Ethylmaleimide solution, and mix. Allow the solution to stand for 5 min before using. Standard solution: 0.05 mg/mL from Standard stock solution in water. [ NOTE-This solution has a concentration equivalent to 0.5% of that of the Sample solution.] System suitability solution: Transfer 10 mg of USP L-Tyrosine RS and 10 mL of the Standard stock solution to a 25-mL volumetric flask. Dilute with water to volume. Sample stock solution: Transfer 0.2 g of Cysteine Hydrochloride to a 10-mL volumetric flask, dissolve, and dilute with water to volume. Sample solution: To 5.0 mL of the Sample stock solution add 5.0 mL of N-Ethylmaleimide solution, and mix. Allow the solution to stand for 5 min before using. Chromatographic system (See Chromatography <621>, Thin-Layer Chromatography.) Mode: TLC Adsorbent: 0.25-mm layer of chromatographic silica gel mixture Application volume: 5μL Developing solvent system: Butyl alcohol, glacial acetic acid, and water (3:1:1) Spray reagent: 2 mg/mL of ninhydrin in a mixture of butyl alcohol and 2N acetic acid (95:5) System suitability Suitability requirements: The chromatogram of the System suitability solution exhibits two clearly separated spots. Analysis Samples: Standard solution, System suitability solution, and Sample solution. After air-drying the plate, spray with Spray reagent, and heat between 100° and 105° for 15 min. Examine the plate under white light. Acceptance criteria: Any secondary spot of the Sample solution is not larger or more intense than the principal spot of the Standard solution. Individual impurities: NMT 0.5% Total impurities: NMT 2.0% SPECIFIC TESTS OPTICAL ROTATION, Specific Rotation <781S> Sample solution: 80 mg/mL in 6 N hydrochloric acid Acceptance criteria: +5.7° to +6.8° LOSSON DRYING <731>: Dry a sample at room temperature at a pressure not exceeding 5 mm of mer cury for 24 h: it loses 8.0%~12.0% of its weight. ADDITIONAL REQUIREMENTS PACKAGING AND STORAGE: Preserve in well-closed containers. USP REFERENCE STANDARDS <11> USP L-Cysteine Hydrochloride RS USP L-Tyrosine RSShanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of L-Cysteine Hydrochloride Monohydrate (H-Cys-OH·HCl·H2O) (CAS: 7048-04-6) with high quality. As one of the largest amino acids suppliers in China, Ruifu Chemical manufactures qualified amino acids derivatives up to international standards, such as AJI , USP, EP, GB, and FCC standard. We can provide COA, worldwide delivery, small and bulk quantities available. If you are interested in L-Cysteine Hydrochloride Monohydrate, Please contact: alvin@ruifuchem.com| Hazard Codes | Xi | RTECS | HA2285000 |
| Risk Statements | 36/37/38 | F | 3-10-23 |
| Safety Statements | 26-36 | TSCA | Yes |
| WGK Germany | 3 | HS Code | 2922491990 |
Description:
Safety Information:
7048-04-6 Test Methods:
| Chemical Name | L-Cysteine Hydrochloride Monohydrate |
| Synonyms | H-Cys-OH·HCl; H-Cys-OH·HCl Monohydrate; H-Cys-OH·HCl·H2O; L-Cys-OH·HCl·H2O; L-Cysteine HCL Monohydrate; L-Cysteine HCl H2O; (R)-2-Amino-3-Mercaptopropanoic Acid Hydrochloride Monohydrate; LCHCMH |
| Stock Status | In Stock, Production Capacity 3000 Tons per Year |
| CAS Number | 7048-04-6 |
| Molecular Formula | C3H10ClNO3S |
| Molecular Weight | 175.64 (157.62 anhy) |
| Melting Point | 175.0~178.0℃ |
| Density | 1.54 g/cm3 |
| Sensitive | Hygroscopic. Air Sensitive, Light Sensitive, Moisture Sensitive |
| Water Solubility | Very Soluble in Water |
| Storage Temp. | Sealed in Dry, Store at Room Temperature |
| COA & MSDS | Available |
| Classification | Amino Acid Derivatives |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White Crystals or Crystalline Powder, Strongly Acid Taste | Conforms |
| Identification | Infrared Absorption Spectrum | Conforms |
| Specific Rotation [α]20/D | +6.1° to +7.8°(C=8,1N HCl) | +6.3° |
| State of Solution (Transmittance) | Clear and Colorless ≥98.0% | 99.1% |
| Chloride (Cl) | 19.89 to 20.29% | 20.16% |
| Sulfate (SO4) | ≤0.020% | <0.020% |
| Ammonium (NH4) | ≤0.020% | <0.020% |
| Iron (Fe) | ≤10ppm | <10ppm |
| Heavy Metals (Pb) | ≤10ppm | <10ppm |
| Arsenic (As2O3) | ≤1.0ppm | <1.0ppm |
| Other Amino Acids | Chromatographically Not Detectable | Conforms |
| Loss on Drying | 8.5 to 12.0% | 9.3% |
| Residue on Ignition (Sulfated) | ≤0.10% | 0.06% |
| Assay | 98.5 to 101.0% (Titration: on Dried Basis) | 99.8% |
| pH Test | 1.5 to 2.0 (1% in Water) | 1.8 |
| Origin | Non-Animal Source | Conforms |
| Residual Solvents | Conforms | Conforms |
| Conclusion | This Product by Inspection Accords with the Standard of AJI97 | |
| Main Uses | Amino Acids; Food Additives; Pharmaceutical Intermediates | |
Application:
L-Cysteine Hydrochloride Monohydrate (H-Cys-OH·HCl·H2O) (CAS: 7048-04-6) is a water-soluble salt of the non-essential amino acid L-cysteine. It is widely used in fields of medicine, food processing, nutritional supplement, antioxidant, color retention agent, biological study, materials of chemical industry and so on. It is a promotor for bread fermentation. It promotes the form of glutelin and prevents from getting ageing. Also used in cosmetic. It is used in natural fruit juice for preventing Vitamin C oxide. It has a detoxification for poison of acrylonitrile aromafic acid. It is used for protecting against radiation harm and therapy of bronchitis and liquefy sputum. L-Cysteine Hydrochloride Monohydrate is mainly used in the field of Medicine: the drug produced can treat leukopenia and leukopenia caused by the administration of anticancer drugs and radioactive drugs clinically. It is an antidote to heavy metal poisoning. It is also used to treat toxic hepatitis, thrombocytopenia, skin ulcer, prevent liver necrosis, and has the effects of treating tracheitis and expectoration. Food grade: nutritional supplement, antioxidants. Bread amendment, promote fermentation, prevent oxidation. In food aspects, as bread crash accelerator, can change the bread and the food flavor. It's hygroscopic. Slow oxidation and decomposition in air. Very soluble in water.Package & Storage:
Package: Fluorinated Bottle, 25kg/bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool, dry and ventilated warehouse away from incompatible substances. Protect from light and moisture.