Irbesartan CAS 138402-11-6 Purity >99.0% (HPLC) API Factory Antihypertensive

Chemical Name: Irbesartan  CAS: 138402-11-6 Purity: >99.0% (HPLC)  Appearance: White to Off-White Crystalline Powder Irbesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension API High Quality, Commercial Production E-Mail: alvin@ruifuchem.com

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Chemical Properties:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureManufacturer Supply, High Purity, Commercial Production  
Item Specifications
Characteristic White to Off-White Crystalline Powder, Slightly soluble in alcohol and in methylene chloride, practically insoluble in water
Identification Infrared Absorption The IR spectrum is in accordance with the spectrum obtained with Irbesartan RS
Identification 2 The retention time of the major peak in the chromatogram of the assay corresponds to Irbesartan RS
Purity / Analysis Method >99.5% (HPLC)  
Water <0.50%
Heavy Metals <0.002% 
Residue on Ignition <0.10%
Related Substances (By HPLC)
USP Impurity A <0.20%
Any Unidentified Impurity <0.10%
Total Impurities <0.50%
Organic VolatileImpurities Meets the requirements of USP
Residual Azide <10ppm
Residual Solvents (By GC)
Ethanol <5000ppm
Toluene <890ppm
Dichloromethane <3000ppm
N,N-Dimethylformamide <880ppm
T-Butyl Methyl Ether <5000ppm
Assay 98.0~102.0% (calculated on anhydrous basis)
Test Standard Enterprise Standard; USP Standard
Usage API; Antihypertensive; For the treatment of hypertension

Description:

Specifications:

Package & Storage:

Chemical Name Irbesartan
Synonyms BMS-186295; SR-47436; Aprovel; Avapro; 2-Butyl-3-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one; 2-Butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
CAS Number 138402-11-6
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C25H28N6O
Molecular Weight 428.54
Density 1.30±0.10 g/cm3
Solubility in Water Insoluble in Water
Brand Ruifu Chemical

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FAQ:

Application:

Irbesartan (CAS: C) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Irbesartan was developed by Sanofi Research (now part of Sanofi-Aventis). It is jointly marketed by Sanofi-Aventis and Bristol-Myers Squibb under the trade names Aprovel, Karvea, and Avapro. Irbesartan is used to treat high blood pressure. Avapro was launched in Germany, the UK and the US for hypertension. As with all angiotensin II receptor antagonists, irbesartan is indicated for the treatment of hypertension. Irbesartan may also delay progression of diabetic nephropathy and is also indicated for the reduction of renal disease progression in patients with type 2 diabetes, hypertension and microalbuminuria (>30 mg/24 hours) or proteinuria. Irbesartan can also reduce electrical remodeling of the myocardium, thereby reduce the mortality rate of patients with hypertension, it is the most effective drug for treatment of hypertension and cardiovascular disease.

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