Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry (≤-20℃) warehouse away from incompatible substances. Protect from light and moisture. Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Bromotripyrrolidinophosphonium Hexafluorophosphate (PyBrOP) (CAS: 132705-51-2) with high quality. Ruifu Chemical supplys a series of protecting reagents and coupling reagents. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase PyBrOP, Please contact: alvin@ruifuchem.comDescription:
Package/Storage/Shipping:
| Chemical Name | Bromotripyrrolidinophosphonium Hexafluorophosphate |
| Synonyms | PyBrOP; Bromo-tris-Pyrrolidinophosphonium Hexafluorophosphate; Bromotri(1-Pyrrolidinyl)phosphonium Hexafluorophosphate |
| Stock Status | In Stock, Mass Production |
| CAS Number | 132705-51-2 |
| Molecular Formula | C12H24BrF6N3P2 |
| Molecular Weight | 466.19 g/mol |
| Melting Point | >100℃ |
| Sensitive | Moisture Sensitive, Heat Sensitive |
| Storage Temp. | Cool & Dry Place (≤-20℃) |
| COA & MSDS | Available |
| Category | Coupling Reagents |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White to Off-White Crystalline Powder | Complies |
| Chloride (Cl) | ≤0.02% | <0.02% |
| Loss on Drying | <0.50% | 0.13% |
| Heavy Metals (Pb) | ≤20ppm | <20ppm |
| Purity / Analysis Method | >99.0% (HPLC) | 99.6% |
| 31P, 19F, 1H NMR spectrum | Consistents | Consistents |
| Elementary Analysis (C,H,N, P, F, Br) | Consistents | Consistents |
| ESI | Consistents | Consistents |
| Conclusion | The product has been tested & complies with the specifications | |
132705-51-2 - Risk and Safety:
Application:
Risk Codes R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. WGK Germany 3 FLUKA BRAND F CODES 10-21 HS Code 2933990099Bromotripyrrolidinophosphonium Hexafluorophosphate (PyBrOP) (CAS: 132705-51-2) is a stable reagent for the coupling of N-Methylamino acids in peptide synthesis. Used for synthesis of depsipeptides. PyBroP is a peptide coupling reagent that has been used in the synthesis of rostate tumor specific peptide-peptoid hybrid prodrugs. A reactive peptide coupling reagent suitable for α,α-dialkyl amino acids. Catalyst for: synthesis of primary amides, direct dehydrative phosphonium cross coupling, direct arylation, pyrrolidide formation by phosphonium salt coupling reagents. PyBroP is a phosphonium salt used in peptide coupling chemistry, analogous to PyCloP. PyBroP shows high efficiency in the coupling of N-methylated amino acids and α,α-disubstituted amino acids, with excellent yields, no epimerisation and fast reaction rates. PyBroP is a stable solid which can be used in a one-pot procedure and is soluble in the solvents commonly used for peptide coupling chemistry. PyBroP is a derivative of the phosphonium coupling reagent BOP but contains a pyrrolidine moiety in place of the dimethylamine of BOP. The aim behind the design of PyBroP was to prevent the formation of the extremely toxic and carcinogenic by-product HMPA generated with BOP, but with comparable performances. PyBroP can be used as a coupling reagent: For Suzuki–Miyaura cross-coupling of phenols and arylboronic acids to synthesize biaryls and heterobiaryls. To functionalize pyrimidines (synthesized from 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via the Kappe dehydrogenation) by using various nucleophiles. To synthesize formamidines by coupling with various primary amines and N,N-diisopropylethylamine. It can also be used as an activating reagent: For the activation of C-OH bond in tautomerizable heterocycles to form the phosphonium salt which aids the Sonogashira coupling of heterocycles with various alkynes. For the one–pot activation of C-O bond in phenols and further coupling reaction with phosphine oxide or phosphite to form C-P bonds.