Chemical Properties:
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.Factory Supply Posaconazole Related Intermediates, Commercial Production Posaconazole CAS 171228-49-2 Posaconazole Intermediate POA CAS 149809-43-8 Phenyl (4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)carbamate CAS 184177-81-9 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine CAS 74853-08-0 2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxal CAS 170985-85-0 Diethyl L-(+)-Tartrate CAS 87-91-2| Item | Specifications |
| Appearance | White to Grey White Powder |
| Identification | IR In accordance with the standard |
| Melting Point | 100.0-102.0℃ |
| Specific Rotation [a]20/D | -40.0° to -48° (C=1, CHCl3) |
| Loss on Drying | ≤0.50% |
| Residue on Ignition | ≤0.20% |
| Heavy Metals | ≤20ppm |
| Related Substances | |
| Major Impurity | ≤0.40% |
| POA-Enantiomer | ≤0.10% |
| POA-Diastereomer | ≤0.20% |
| Individual Unknown Impurity | ≤0.20% |
| Total Impurities | ≤1.0% |
| Purity | ≥99.0% |
| Assay | 98.0%~102.0% (anhydrous substance) |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Posaconazole (CAS 171228-49-2) |
Description:
Specifications:
Package & Storage:
| Name | Posaconazole Intermediate POA |
| Synonyms | (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester; (3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate |
| CAS Number | 149809-43-8 |
| CAT Number | RF-PI291 |
| Stock Status | In Stock, Production Scale Up to Hundreds of Kilograms |
| Molecular Formula | C21H21F2N3O4S |
| Molecular Weight | 449.47 |
| Density | 1.40 |
| Shipping Condition | Shipped Under Ambient Temperature |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester (CAS 149809-43-8) is the Intermediate of Posaconazole (CAS 171228-49-2). Posaconazole is a triazole antifungal agent that blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of methylated sterol precursors, more potent at inhibiting 14α-demethylase than itraconazole.
