Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureRuifu Chemical Supply Palbociclib Related Intermediates: Palbociclib CAS 571190-30-2 5-Bromo-2,4-Dichloropyrimidine CAS 36082-50-5 5-Bromo-2-Chloro-N-Cyclopentylpyrimidin-4-Amine CAS 733039-20-8 tert-Butyl 4-(6-Nitropyridin-3-yl)piperazine-1-Carboxylate CAS 571189-16-7 tert-Butyl 4-(6-Amino-3-Pyridyl)piperazine-1-Carboxylate CAS 571188-59-5 6-Bromo-2-Chloro-8-Cyclopentyl-5-Methylpyrido-[2,3-d]pyrimidin-7(8H)-one CAS 1016636-76-2 2-Chloro-8-Cyclopentyl-5-Methyl-8H-Pyrido[2,3-d]pyrimidin-7-one CAS 1013916-37-4| Item | Specifications |
| Appearance | Faint Yellow Powder |
| Purity / Analysis Method | >99.0% (HPLC) |
| Moisture (K.F) | <0.50% |
| Residue on Ignition | <0.20% |
| Total Impurities | <1.00% |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Palbociclib (CAS: 571190-30-2) |
Description:
Specifications:
Package & Storage:
| Chemical Name | 2-Chloro-8-Cyclopentyl-5-Methyl-8H-Pyrido[2,3-d]pyrimidin-7-one |
| Synonyms | 2-Chloro-8-Cyclopentyl-5-Methylpyrido[2,3-d]pyrimidin-7(8H)-one; Palbociclib Intermediate 2 |
| CAS Number | 1013916-37-4 |
| CAT Number | RF-PI1847 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C13H14ClN3O |
| Molecular Weight | 263.72 |
| Water Solubility | Slightly Soluble in Water |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (CAS: 1013916-37-4) is used as a pharmaceutical intermediate of Palbociclib (CAS: 571190-30-2). Palbociclib is a drug for the treatment of ER-positive and HER2-negative breast cancer developed. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.Palbociclib was the first CDK4/6 inhibitor to be approved as a cancer therapy by any organization, and as of December 2017 has been prescribed more than 90,000 times.
