Chemical Properties:
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture. Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of N-Cbz-L-Valine (Z-Val-OH) (CAS: 1149-26-4) with high quality. Ruifu Chemical supplys a series of amino acids. We can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase N-Cbz-L-Valine, Please contact: alvin@ruifuchem.comDescription:
Package/Storage/Shipping:
| Chemical Name | N-Cbz-L-Valine |
| Synonyms | Z-Val-OH; Z-L-Val-OH; Z-L-Valine; N-Carbobenzoxy-L-Valine; N-Benzyloxycarbonyl-L-Valine |
| Stock Status | In Stock, Production Capacity to Tons per Month |
| CAS Number | 1149-26-4 |
| Molecular Formula | C13H17NO4 |
| Molecular Weight | 251.28 g/mol |
| Melting Point | 57.0~63.0℃ |
| Density | 1.182 |
| Solubility in Methanol | Almost Transparency |
| Storage Temp. | Cool & Dry Place (2~8℃) |
| COA & MSDS | Available |
| Category | Z-Amino Acids |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White Crystal Powder | Complies |
| Specific Rotation [α]20/D | -4.0°±1.0° (C=2 in AcOH) | -3.8° |
| Melting Point | 57.0~63.0℃ | 58.0~61.0℃ |
| Water by Karl Fischer | <0.50% | 0.20% |
| Sulfate Ash | <0.20% | 0.09% |
| Optical Purity | <0.50% D-Enantiomer | Complies |
| Individual Max. Unknown Impurity | <0.50% | Complies |
| Purity / Analysis Method | >99.0% (HPLC) | 99.5% |
| Purity (Neutralization Titration) | 98.5~101.5% | Complies |
| Infrared Spectrum | Conforms to Structure | Complies |
| NMR Spectrum | Conforms to Structure | Complies |
| Conclusion | The product has been tested & complies with the specifications | |
1149-26-4 - Risk and Safety:
Application:
Risk Codes R38 - Irritating to the skin R43 - May cause sensitization by skin contact R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. Safety Description S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. WGK Germany 3 HS Code 2922491990 Hazard Note IrritantN-Cbz-L-Valine (Z-Val-OH) (CAS: 1149-26-4) is an N-Cbz-protected form of L-Valine. N-Cbz-L-Valine is a valine protected by Cbz and is widely used in the field of drug synthesis. L-Valine is an essential amino acid that is used as an ingredient in cosmetic formulations, pharmaceuticals, and animal feed products. L-Valine is also important for growth and ammonia detoxification in humans. Z-Amino Acid, can be used in peptide synthesis, can be also used as an organic synthesis intermediate, pharmaceutical intermediate, biochemical reagent or chemical reagent. N-Cbz-L-Valine can be used in the manufacturing of API's like Imatinib, Valaciclovir. Preparation take 1.17Kg (10mol) of L-Valine, 5L of 2mol/L sodium hydroxide solution and 1.06Kg (10mol) of sodium carbonate into a 20L reaction kettle, start stirring, after L-Valine is completely dissolved, reduce the temperature of the solution to below 0℃, and drip 1 containing 2.05Kg(12mol) of benzyl chloroformate, 4-dioxane solution 5L, the temperature of the solution in the dropping process is kept below 20℃, after dropping, the reaction is 8h at room temperature. At the end of the reaction, the reaction liquid is extracted with dichloromethane 2.5L, the organic phase is discarded, the aqueous phase is cooled to below 10℃, concentrated hydrochloric acid is dropped until pH=2, then stirred at 10℃ for 30min, a large amount of white solid is precipitated, filtration is carried out, the filter residue is washed with water, the white solid is put into a vacuum drying oven to dry, and the yield is 93.7%.