Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.Manufacturer Commercial Supply Macitentan Related Intermediates 5-(4-Bromophenyl)-4,6-Dichloropyrimidine CAS 146533-41-7 5-Bromo-2-Chloropyrimidine CAS 32779-36-5| Item | Specifications |
| Appearance | White to Off-White Powder |
| Identification | IR/HPLC |
| Purity / Analysis Method | ≥99.5% (HPLC) |
| Moisture (K.F) | ≤0.50% |
| Residue on Ignition | ≤0.20% |
| Single Impurity | ≤0.30% |
| Total Impurities | ≤0.50% |
| Test Standard | Enterprise Standard |
| Usage | Pharmaceutical Intermediates; Macitentan Intermediate |
Description:
Specifications:
Package & Storage:
| Chemical Name | 5-Bromo-2-Chloropyrimidine |
| Synonyms | 2-Chloro-5-Bromopyrimidine; Macitentan Intermediate 5 |
| CAS Number | 32779-36-5 |
| CAT Number | RF-PI854 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C4H2BrClN2 |
| Molecular Weight | 193.43 |
| Melting Point | 73.0~79.0℃ (lit.) |
| Boiling Point | 95℃/15 mmHg |
| Solubility | Soluble in Methanol; Insoluble in Water |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
5-Bromo-2-Chloropyrimidine (CAS: 32779-36-5) is applied as a pharmaceutical intermediate, in the synthesis of Active Pharmaceutical Ingredients (APIs). It is also employed in the cross-coupling reactions of indium organometallics with 2,5-Dihalopyrimidines. 5-Bromo-2-Chloropyrimidine is the intermediate of Macitentan (CAS: 441798-33-0). Macitentan received US FDA approval in October 2013 for the treatment of pulmonary arterial hypertension (PAH) (WHO group I) to delay disease progression.
