Chemical Properties:
Package: Plastic vial (dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement. Storage Condition: Store in sealed containers at cool and dry (-20℃) warehouse away from incompatible substances. Protect from light and moisture. Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Desmopressin Acetate (CAS: 16789-98-3) with high quality. Ruifu Chemical supplys a series of GMP peptides. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase Desmopressin Acetate, Please contact: alvin@ruifuchem.comDescription:
Package/Storage/Shipping:
| Chemical Name | Desmopressin Acetate |
| Synonyms | Desmopressin (Acetate); DDAVP; 1-(3-Mercaptopropanoic Acid)-8-d-Arginine Vasopressin Monoacetate; 8-d-Arginine-1-(3-Mercapto-Propanoic Acid)vasopresin Monoacetate; Adiuretin SD; Desmospray; Minirin; Octim; Octostim; Presinex; Stimate |
| Sequence | Mpr-Tyr-Phe-Gln-Asn-Cys-Pro-DArg-Gly-NH2 (Mpr1 & Cys6 Bridge) |
| Stock Status | In Stock |
| CAS Number | 16789-98-3 |
| Molecular Formula | C46H64N14O12S2.2(C2H4O2) |
| Molecular Weight | 1189.32 g/mol |
| Sensitive | Hygroscopic. Moisture Sensitive |
| Storage Temp. | Cool & Dry Place (-20℃). Refrigerator Under Inert Atmosphere |
| COA & MSDS | Available |
| Expiry Date | 24 Months From Manufacture Date if Stored Properly |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White Fluffy Powder | Complies |
| Identity by HPLC | The Retention is Same with the Reference Substance | Complies |
| Specific Rotation [α]20/D | -72.0° to -82.0° (C=1, 1% HAc) | -75.7° |
| Amino Acid Composition | Asp: 0.95~1.05 | 0.98 |
| Glu: 0.95~1.05 | 0.98 | |
| Pro: 0.95~1.05 | 1.01 | |
| Gly: 0.95~1.05 | 1.00 | |
| Arg: 0.95~1.05 | 1.01 | |
| Phe: 0.95~1.05 | 0.97 | |
| Tyr: 0.70~1.05 | 0.99 | |
| Cys: 0.30~1.05 | 0.78 | |
| Peptide Purity (HPLC) | ≥98.5% | 99.3% |
| Related Substance ( HPLC) | Total Impurities: ≤ 1.5% | 0.78% |
| Largest Single Impurity: ≤ 0.5% | 0.16% | |
| Acetate Content (HPLC) | 3.0~8.0% | 7.6% |
| Water Content (Karl Fischer) | ≤6.0% | 1.0% |
| Sterility | ≤50 CFU/100 mg | Complies |
| Bacterial Endotoxins | ≤5 IU/mg | Complies |
| Assay | 95.0~105.0% (Anhydrous, Acetic Acid Free) | 98.6% |
| Origin of Product | Synthetic | Synthetic |
| Attention | Only for Research, Not for Human Use | |
| Conclusion | The product has been tested & complies with the specifications | |
16789-98-3 - Risk and Safety:
Application:
Hazard Symbols Xn - Harmful Risk Codes 20 - Harmful by inhalation Safety Description 36 - Wear suitable protective clothing. WGK Germany 3Desmopressin Acetate (CAS: 16789-98-3) that is, 1-cysteine deamination and 8-D-arginine instead of 8-l-arginine, also known as arginine vasopressin, is a structural analog of natural arginine vasopressin, a derivative of vasopressin, its antidiuretic effect is more powerful and lasting than vasopressin, but no vasoconstrictor effect, drug side effects, clinical for congenital or drug-induced platelet dysfunction, uremia, liver cirrhosis and unknown causes caused by prolonged bleeding time; Can be used to control and prevent bleeding during small surgery; Central diabetes insipidus. In individual cases, this product will even produce efficacy in patients with moderate urinary system diseases, often disabled in patients with Type IIB von Willebrand disease. Pharmacological action: Desmopressin Acetate contains desmopressin that is structurally similar to native arginine vasopressin. It is the difference between arginine vasopressin, mainly for the half of the amino acid and D arginine to replace L Arginine. These structural changes prolong the duration of action of the clinical dose of desmopressin without the side effects of compression. Some studies have shown that the effect of anti-enuresis is significant, which may be due to the increase of arginine vasopressin levels in the blood of children at night, and then concentrate the urine, reduce the urine volume and intravascular pressure, decreased neck and detrusor contraction. Its efficacy, ease of administration (intranasal), long duration of action, and lack of side effects make itthe drug of choice for the treatment of central diabetesinsipidus. It may also be administered intramuscularly orintravenously. It is preferred to vasopressin injectionand oral antidiuretics for use in children. It is indicatedin the management of temporary polydipsia and polyuriaassociated with trauma to, or surgery in, the pituitary region. Clinical Use: Desmopressin, as its acetate salt, is a synthetic analogue of vasopressin in which the Nterminal Cys is devoid of its α-amino function (1-Deamino) and where Arg8 is present as its D-isomer (D-Arg8), thus the commercial acronym DDAVP. The presence of D-Arg and the absence of the N-terminal amine in the desmopressin structure have increased its half-life such that it is available for oral, parenteral, or nasal use. It is used by all three of these routes of administration to prevent or control polydipsia (excessive thirst), polyuria, and dehydration of patients with diabetes insipidus caused by a deficiency of vasopressin. It also has been approved for the treatment of nocturnal enuresis (bed-wetting), which is believed to be caused by an absence of the normal night time rise in vasopressin levels. Desmopressin is known to cause an increase in both plasma factor VIII (antihemophilic factor) and plasminogen activator. It therefore is approved by the U.S. FDA for use, parenterally and nasally, in reducing spontaneous or trauma-induced bleeding episodes in patients with hemophilia A and type I Von Willebrand's disease, provided that their plasma factor VIII activity is greater than 5%. Stimate, the nasal spray used in treating patients with hemophilia A and type I Von Willebrand's disease, is 15-fold the concentration of DDAVP nasal spray; the latter is used in treating diabetes insipidus.