Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureManufacturer Supply, High Quality and Competitive Price Tipiracil Hydrochloride (CAS: 183204-72-0) Related Intermediates 6-(Chloromethyl)uracil CAS: 18592-13-7 6-(Hydroxymethyl)uracil CAS: 22126-44-9 2-Amino-1-Pyrroline Hydrochloride CAS 7544-75-4| Item | Specifications | Results |
| Appearance | White Powder | White Powder |
| Purity / Analysis Method | >99.5% (HPLC) | 99.8% |
| Largest Single Impurity | <0.50% | 0.09% |
| Water Content (K.F) | <0.50% | 0.45% |
| Proton NMR Spectrum | Conforms to Structure | Conforms |
| Test Standard | Enterprise Standard | |
| Usage | Intermediate of Tipiracil Hydrochloride (CAS: 183204-72-0) | |
Description:
Specifications:
Package & Storage:
| Chemical Name | 2-Amino-1-Pyrroline Hydrochloride |
| Synonyms | 3,4-Dihydro-2H-Pyrrol-5-Amine Hydrochloride; 2-Aminopyrrolidine HCl |
| CAS Number | 7544-75-4 |
| CAT Number | RF-PI1838 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C4H8N2·HCl |
| Molecular Weight | 120.58 |
| Melting Point | 171.0 to 175.0℃ |
| Sensitive | Hygroscopic |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
2-Amino-1-Pyrroline Hydrochloride (CAS: 7544-75-4) is a heterocyclic organic compound, which can be used as a pharmaceutical intermediate. 2-Amino-1-Pyrroline Hydrochloride is an intermediate of Tipiracil Hydrochloride (CAS: 183204-72-0) in the treatment of Rectal Cancer. Tipiracil Hydrochloride is a potent and competitive inhibitor of thymidine phosphorylase (TPase) with an IC50 value of 35 nM for human placental TPase. It is selective for TPase over other pyrimidine-metabolizing enzymes (IC50s = >1 mM for UPase, OPRTase, TK, and DPDase). TPI inhibits the phosphorolysis and degradation of trifluorothymidine, a cytotoxic nucleoside, in human breast and colon carcinoma tumor samples. Oral administration of TPI (12.5-50 mg/kg) enhances the anti-tumor activity of trifluorothymidine in a mouse AZ-521 stomach cancer xenograft model. Formulations containing TPI have been used for the treatment of metastatic colorectal cancer.
