Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture. Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of HCTU (CAS: 330645-87-9) with high quality. Ruifu Chemical supplys a series of protecting reagents and coupling reagents. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase HCTU (CAS: 330645-87-9), Please contact: alvin@ruifuchem.comDescription:
Package/Storage/Shipping:
| Chemical Name | HCTU |
| Synonyms | O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-Tetramethyluronium Hexafluorophosphate; 1-[Bis(dimethylamino)methylen]-5-Chlorobenzotriazolium 3-oxide Hexafluorophosphate; N,N,N′,N′-Tetramethyl-O-(6-Chloro-1H-benzotriazol-1-yl)uronium Hexafluorophosphate; 5-Chloro-1-[Bis(dimethylamino)methylene]-1H-Benzotriazolium 3-oxide Hexafluorophosphate |
| Stock Status | In Stock, Commercial Scale |
| CAS Number | 330645-87-9 |
| Molecular Formula | C11H15ClF6N5OP |
| Molecular Weight | 413.69 g/mol |
| Melting Point | 185.0~191.0℃ |
| Sensitive | Hygroscopic. Moisture Sensitive, Light Sensitive, Heat Sensitive |
| Solubility | Soluble in Dimethylformamide |
| Storage Temp. | Cool & Dry Place (2~8℃) |
| COA & MSDS | Available |
| Category | Coupling Reagents |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White to Off-White Crystalline Powder | Complies |
| Melting Point | 185.0~191.0℃ | 186.7℃ |
| Water by Karl Fischer | <0.50% | 0.10% |
| Loss on Drying | <0.50% | 0.12% |
| Purity / Analysis Method | >99.0% (HPLC) | 99.67% |
| Solution Test | 0.3gram in 2 ml DMF Clear Solution | Complies |
| Infrared Spectrum | Conforms to Structure | Complies |
| NMR Spectrum | Conforms to Structure | Complies |
| Conclusion | The product has been tested & complies with the specifications | |
330645-87-9 - Risk and Safety:
Application:
Risk Codes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. WGK Germany 3 FLUKA BRAND F CODES 10 HS Code 2933990099HCTU (CAS: 330645-87-9) is a novel aminium-based coupling reagent used during the process of solid phase peptide synthesis (SPPS), analogous to HBTU, which in comparative studies was found to give superiort results to TBTU in the synthesis of difficult peptides, in hindered couplings, and cyclizations. Peptide synthesis is important within chemistry, allowing us to create new peptides and bonds (this is the backbone of proteins). HCTU is a highly efficient coupling reagent that could be used as a low-cost alternative to more expensive, highly efficient reagents such as HATU when fast coupling times (5 min or less) are desired. Fast coupling times promote increased productivity, and in some cases may also result in purer crude peptides by not allowing kinetically slower side reactions to compete. HCTU is a coupling reagent used for amide and ester formation and commonly employed in peptide synthesis. HCTU is analogous to HBTU and has a Cl substituent on the phenyl ring in the 6 position. HCTU is non-toxic, stable in DMF, suitable for solid-phase and in solution synthesis. High purities, short reaction times and high coupling efficiency can be achieved when HCTU is employed, with performances comparable to HATU but at a more affordable price. HCTU is a reagent for the synthesis of near-infrared pH activatable fluorescent probes and of human β-amyloid by Fmoc chemistry. HCTU is also a reagent for stereoselective Horner-Wadsworth-Emmons olefination, covalent ligation of fluorescent peptides to quantum dots, and alkylation of human telomere sequence.