Chemical Properties:
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture.Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of D-Tryptophan Methyl Ester Hydrochloride (H-D-Trp-OMe·HCl) (CAS: 14907-27-8) with high quality. Ruifu Chemical supplys amino acids and derivatives. We can provide worldwide delivery, small and bulk quantities available. Purchase H-D-Trp-OMe·HCl, Please contact: alvin@ruifuchem.com| Safety Statements | 24/25 | WGK Germany | 3 |
| HS Code | 2922491990 |
Description:
Safety Information:
Package & Storage:
| Chemical Name | D-Tryptophan Methyl Ester Hydrochloride |
| Synonyms | H-D-Trp-OMe·HCl; Methyl D-Tryptophanate Hydrochloride; (R)-Tryptophan Methyl Ester Monohydrochloride; (R)-Tryptophane Methyl Ester Hydrochloride |
| Stock Status | In Stock |
| CAS Number | 14907-27-8 |
| Molecular Formula | C12H14N2O2·HCl |
| Molecular Weight | 254.71 g/mol |
| Melting Point | 210.0~220.0℃ |
| Density | 1.337g/cm3 at 20℃ |
| Solubility | Soluble in Methanol |
| Storage Temp. | Cool & Dry Place (2~8℃) |
| COA & MSDS | Available |
| Category | Amino Acids Derivatives |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White to Off-White Powder | White Powder |
| Specific Rotation [α]20/D | -18.0°±2.0° (C=5 in MeOH) | -18.3° |
| TLC Analysis | ≥99.0% | >99.0% |
| Melting Point | 210.0~220.0℃ | 213.0~216.0℃ |
| Loss on Drying | <0.50% | 0.20% |
| Residue on Ignition | <0.20% | 0.07% |
| Heavy Metals (Pb) | ≤20ppm | <20ppm |
| Assay / Analysis Method | >99.0% (HPLC) | 99.5% |
| Clarity of Solution | 0.3 gram in 2ml H2O Clear Solution | Complies |
| Mass Spectrum | In Accordance With the Standard | Complies |
| NMR Spectrum | In Accordance With the Standard | Complies |
| Conclusion | This Product by Inspection Accords with the Enterprise Standard | |
Application:
D-Tryptophan Methyl Ester Hydrochloride (H-D-Trp-OMe·HCl) (CAS: 14907-27-8) is an intermediate in the synthesis of Tryptophan derivatives; Useful as an intermediate in the drug substance Tadalafil (CAS: 171596-29-5) for the treatment of male erectile dysfunction; An intermediate of Tadalafil. Tadalafil was marketed in the United States in December 2003 as a daily oral dosage form. It is also approved in the United States and Europe for benign prostatic hyperplasia and pulmonary hypertension. Amino acids derivatives, used in peptide synthesis, organic synthesis intermediates, pharmaceutical intermediates, biochemical reagents, chemical reagents. Preparation of D-Tryptophan Methyl Ester Hydrochloride: D-Tryptophan (50g) is added to the mixed solution of toluene (650ml) and methanol (105ml) and stirred evenly, slowly dropwise addition of thionyl chloride (38.6g) at 0 degrees Celsius, after the dropwise addition, the temperature is raised to 75-80 degrees Celsius for 4 hours, the reaction is over, the reaction liquid is cooled to 0 degrees, the solid was precipitated, filtered, the filter cake was washed with toluene, and dried in vacuum at 50℃ for 6h to obtain D-Tryptophan Methyl Ester Hydrochloride. The yield was 95% and the HPLC purity was 99%.