Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.Manufacturer Supply Linagliptin and Related Intermediates: Linagliptin CAS 668270-12-0 Linagliptin Parent Nucleus Intermediate CAS 853029-57-9 8-Bromo-3-Methylxanthine CAS 93703-24-3 8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine CAS 666816-98-4 2-(Chloromethyl)-4-Methylquinazoline CAS 109113-72-6 (R)-3-(Boc-Amino)piperidine CAS 309956-78-3 (R)-(-)-3-Aminopiperidine Dihydrochloride CAS 334618-23-4 1-Bromo-2-Butyne CAS 3355-28-0Item | Specifications |
Appearance | White to Light Yellow Powder |
Identification | IR/HPLC |
Purity | ≥99.0% |
Water (K.F) | ≤1.0% |
Residue on Ignition | ≤0.50% |
Total Impurities | ≤1.0% |
Test Standard | Enterprise Standard |
Usage | Intermediate for Linagliptin (CAS: 668270-12-0) |
Description:
Specifications:
Package & Storage:
Chemical Name | 8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione |
Synonyms | Linagliptin Parent Nucleus; Linagliptin Intermediate F |
CAS Number | 853029-57-9 |
CAT Number | RF-PI502 |
Stock Status | In Stock, Production Scale Up to Tons |
Molecular Formula | C20H17BrN6O2 |
Molecular Weight | 453.29 |
Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
8-Bromo-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (CAS: 853029-57-9) is the parent nucleus of Linagliptin (CAS: 668270-12-0). Linagliptin (trade names Tradjenta and Trajetna) is an inhibitor of dipeptidyl peptidase-4 (DPP-4) that was approved by the U.S. FDA in May 2011 for the treatment of Type 2 diabetes along with diet and exercise. Linagliptin (BI-1356) has been described as a potent highly selective, slow-off rate and long acting inhibitor of DPP-4. Linagliptin arose from optimization efforts of xanthine-based DPP-4 inhibitors with the initial lead identified from an HTS campaign.