Chemical Properties:
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.Commercial Supply LCZ696 (CAS: 936623-90-4) Related Intermediates: (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1 (R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8 (2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2 (2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0 AHU-377 (hemicalcium salt) CAS: 1369773-39-6 AHU-377; Sacubitril CAS: 149709-62-6 LCZ696; Entresto; Sacubitril mixture with Valsartan CAS: 936623-90-4| Item | Specifications |
| Appearance | White to Off-White Powder |
| Purity / Analysis Method | ≥98.0% (HPLC) |
| Enantiomeric Excess | e.e: ≥99.0% |
| Moisture (K.F) | ≤1.0% |
| Related Substances A | ≤1.0% (RRT=0.5) A=(R)-3-([1,1'-biphenyl]-4-yl)-2-aminopropan-1-ol |
| Related Substances B | ≤1.0% (RRT=0.85) B=Triphenylphosphine oxide |
| Other Substances | ≤1.0% |
| Total Impurities | ≤2.0% |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of LCZ696 (CAS: 936623-90-4) in the treatment of HFrEF |
Description:
Specifications:
Package & Storage:
| Chemical Name | (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate |
| Synonyms | LCZ696 Intermediate |
| CAS Number | 1426129-50-1 |
| CAT Number | RF-PI169 |
| Stock Status | In Stock, Production Scale Up to Hundreds of Kilograms |
| Molecular Formula | C20H25NO3 |
| Molecular Weight | 327.42 |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
Manufacturer with High Purity and Stable Quality Commercial Supply LCZ696 (CAS: 936623-90-4) Related Intermediates: (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1 (R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8 (2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2 (2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0 AHU-377 (hemicalcium salt) CAS: 1369773-39-6 AHU-377; Sacubitril CAS: 149709-62-6 LCZ696; Entresto; Sacubitril mixture with Valsartan CAS: 936623-90-4 LCZ696 is an experimental drug developed by Novartis Pharmaceutical of the United States for the treatment of patients with Heart Failure with reduced Ejection Fraction (HFrEF). Heart failure is a life-threatening disease. The patient's heart cannot pump enough blood to supply the body, and appear the symptoms of dyspnea, fatigue and fluid retention slowly, then gradually increased, significantly affect the quality of life. LCZ696 can enhance the body's natural defense against heart failure, as well as increase the level of natriuretic peptides and other endogenous vasoactive peptides, and inhibit the renin-angiotensin-aldosterone system (RAAS). LCZ696 has combined with Novartis's Hypertension Medication (Diovan, generic name: valsartan) and the experimental drug AHU-377. AHU377 blocks the mechanism of the two peptides responsible for lowering blood pressure. Diovan improves vasodilatation and stimulates the body to excrete sodium and water.
