Ethyl (S)-4-Chloro-3-hydroxybutyrate CAS 86728-85-0 Atorvastatin Calcium Intermediate

Chemical Name: Ethyl (S)-4-Chloro-3-hydroxybutyrate CAS: 86728-85-0 Appearance: Colorless to Pale Yellow Liquid Purity: ≥98.0% (GC)   Intermediate of Atorvastatin Calcium (CAS: 134523-03-8)   Inquiry: alvin@ruifuchem.com

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Chemical Properties:

Package: Bottle, Barrel, 25kg/Barrel, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Item Specifications
Appearance Colorless to Pale Yellow Liquid
Purity / Analysis Method ≥98.0% (GC) 
Moisture (K.F) ≤0.50%
Ethyl-4-Chloro Aceto Acetate ≤0.50%
Test Standard Enterprise Standard
Usage Pharmaceutical Intermediate; Organic Synthesis
Ethyl (S)-4-Chloro-3-hydroxybutyrate (CAS: 86728-85-0) Method of analysis Description Take about 10ml sample in a clean and dry glass plate and check. Specific rotation Transfer accurately about 1.0g of sample to 100ml volumetric flask and dissolved in 10 ml of chloroform, then dilute with chloroform to 100ml and mix. Measure the optical rotation of the test sample at 25ºC and 589nm wavelength calculate the specific rotation as per the given formula. [α]25D = (v×a)/[w×(1-b)] [α]25D: the specific rotation of test sample; α: the observed rotation in angular degree; w: sample weight (g); v: volume (mL); b: Water content(%) Purity (by GC) Chromatographic conditions: The Gas chromatography is equipped with flame ionization detector Column: SE-54, 30m×0.35mm×0.25µm Oven temperature: Initial temp 120℃, Hold time for 2min Ramp: 20℃/min Temp: 250℃, Hold time for 2min Injector temperature: 250℃ Detector temperature: 250℃(FID) Injection volume: 0.2µl Sample solution: dilute 1ml A4 with 1ml acetone. Procedure: Inject 0.2µl of the acetone as blank and record the chromatogram. In the chromatogram obtained from diluent there should not be any interference at the retention time of the main peak and impurity peak. Than Inject the sample solution in duplicate into the chromatograph and record the chromatogram. Report the Purity of sample by area normalization method.

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Chemical Name Ethyl (S)-4-Chloro-3-hydroxybutyrate
Synonyms (S)-4-Chloro-3-hydroxybutyric Acid Ethyl Ester
CAS Number 86728-85-0
CAT Number RF-PI139
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C6H11ClO3
Molecular Weight 166.6
Density  1.19 g/mL at 25℃ (lit.)
Refractive Index  n20/D 1.453 (lit.)
Brand Ruifu Chemical

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Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Ethyl (S)-4-Chloro-3-hydroxybutyrate (CAS: 86728-85-0) with high quality, it is an intermediate typically in the synthesis of Atorvastatin Calcium (CAS: 134523-03-8).    Atorvastatin Calcium (CAS: 134523-03-8) [trade name: Lipitor]  is mainly indicated for the treatment of cardiovascular disease and dyslipidemia due to its effect in lowering the cholesterol in the blood. Atorvastatin acts primarily in the liver. Decreased hepatic cholesterol levels further increases hepatic uptake of cholesterol and reduces plasma cholesterol levels. Lipitor, since 1996, has become the world's best-selling medication to that point. 

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