Chemical Properties:
Package: Bottle, 25kg/Drum, or according to customer's requirement. Storage Condition: Moisture Sensitive, store away from water/moisture. Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of N,N'-Dicyclohexylcarbodiimide (DCC) (CAS: 538-75-0) with high quality. Ruifu Chemical supplys a series of protecting reagents and coupling reagents. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase DCC, Please contact: alvin@ruifuchem.com| Item | Specifications |
| Appearance | White Crystal or Light Yellow Liquid |
| Purity / Analysis Method | >99.0% (GC) |
| Melting Point | 32.0℃～36.0℃ |
| Loss on Drying | <0.50% |
| Solution Test (In Acetone) | Clear & Transparent |
| Insoluble Matter In Acetone | None |
| Total Impurities | <1.00% |
| Storage | Protect form the light and store in a cool and dry place |
| Test Standard | Enterprise Standard |
| Usage | Peptide Coupling Reagents |
Description:
Specifications:
Package & Storage:
| Chemical Name | N,N'-Dicyclohexylcarbodiimide |
| Synonyms | DCC; Dicyclohexylcarbodiimide |
| CAS Number | 538-75-0 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C13H22N2 |
| Molecular Weight | 206.33 |
| Melting Point | 32.0~36.0℃ |
| Boiling Point | 122.0~124.0℃/6 mm Hg(lit.) |
| Density | 1.247 g/mL at 25℃ |
| Sensitive | Moisture Sensitive |
| Solubility in Water | Insoluble in Water |
| Solubility | Soluble in Methanol |
| Storage Temp. | Cool & Dry Place (2~8℃) |
| COA & MSDS | Available |
| Category | Coupling Reagents |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
538-75-0 - Risk and Safety:
Risk Codes R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R34 - Causes burns R40 - Limited evidence of a carcinogenic effect R43 - May cause sensitization by skin contact R41 - Risk of serious damage to eyes R36/38 - Irritating to eyes and skin. R21 - Harmful in contact with skin R24 - Toxic in contact with skin R22 - Harmful if swallowed R62 - Possible risk of impaired fertility R37/38 - Irritating to respiratory system and skin. R10 - Flammable R61 - May cause harm to the unborn child R26 - Very Toxic by inhalation R38 - Irritating to the skin R20/22 - Harmful by inhalation and if swallowed. Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S41 - In case of fire and / or explosion do not breathe fumes. S24 - Avoid contact with skin. S37/39 - Wear suitable gloves and eye/face protection S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S16 - Keep away from sources of ignition. S53 - Avoid exposure - obtain special instructions before use. S28 - After contact with skin, wash immediately with plenty of soap-suds. UN IDs UN 2922 8/PG 2 WGK Germany 3 RTECS FF2160000 FLUKA BRAND F CODES 3-8-10-21 TSCA Yes HS Code 2925290090 Hazard Class 6.1 Packing Group II Toxicity LD50 orally in Rabbit: 1110 mg/kg LD50 dermal Rat 71 mg/kgSufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Method of Analysis:
1 Purpose Clarify the inspection procedure of DCC. 2 Range Applicable to the inspection of DCC in Ruifu company. 3 Basis Chinese Pharmacopoeia 2005 edition, enterprise internal control standard. 4. Responsibility 4.1 The Quality Department is responsible for training and guidance. 4.2 The analyst shall be responsible for the specific operation and the accuracy of the test results. 5 Operation Procedures 5.1 Properties: This product is white crystal or light yellow liquid. Take 100 grams of sample and place it in a beaker, cool it to the freezing point temperature, and then heat it up to melt. Observe the color and crystal separately 5.2 Freezing point Put 15ml sample into 20ml test tube. The sample completely melted when heated at 45℃. Transfer the test tube into a water bath at 25℃ In, stir and insert thermometer seal. Every 30 seconds until the liquid solidifies, then every 15 seconds, The temperature shown is the freezing point until the thermometer remains unchanged for about 1min. 5.3 Content determination Determination by gas chromatography (Appendix of Chinese Pharmacopoeia 2005 Edition). Instrument: Kexiao GC1690 gas Chromatograph column: ATSE-54 Column temperature: 230℃ Carrier gas: nitrogen Detection temperature: 300℃ Injection temperature: 280℃ Shunt ratio: 50:1 Detector: FID Inject 0.2ul of test solution into the chromatograph for 15 min. Quantified by area normalization method. 5.4 Results Calculated by area normalization method, the DCC shall not be less than 99.0%.Application:
DCC (N,N'-Dicyclohexylcarbodiimide, CAS: 538-75-0) is used in peptide chemistry as a coupling reagent. Mainly used for the artificial synthesis of peptides Condensation of amino acids. For example, in Fmoc-solid phase synthesis, the carboxyl group of an amino acid forms an amide bond with the amino group of another amino acid. In order to make the carboxyl group more receptive to the attack of nucleophiles, the negatively charged oxygen atom needs to be activated into a better leaving group, and DCC plays this role. The oxygen atom of the carboxyl group on the amino acid acts as a nucleophile to attack the carbon atom in the middle of the DCC molecule so that the DCC combines with the carboxyl group to form an ester structure, making the nucleophilic attack of the amino group easy to carry out coupling reagent. DCC is used for the synthesis and dehydration of amikacin and amino acids. it is a good low-temperature biochemical dehydrating agent and is also used for the synthesis of acids, anhydrides, aldehydes, ketones, etc. In Japan, dehydrating agents used for glutathione account for 90% of total consumption. When the product is used as a dehydration and condensing agent, it can be reacted in a short time at room temperature, and the product after the reaction is dicyclohexylurea. Since the solubility of the product in the organic solvent is very small, the reaction product is easy to separate; at the same time, because the product is difficult to dissolve in water, the reaction can still proceed even in an aqueous solution. The product is also used for the synthesis of peptides and nucleic acids. The use of this product can easily synthesize peptides from compounds with free carboxyl groups and compounds with free amino groups at room temperature, and the yield is very high. Used for the production of hypertensives and cyclic adenosine monophosphate. used as biochemical reagent and organic synthesis dehydration condensing agent.