Chemical Properties:
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.Supply with High Purity and Stable Quality Chemical Name: Dantrolene Sodium Salt Hydrate CAS: 14663-23-1 Skeletal Muscle Relaxant. Calcium Channel Inhibitor API High Quality, Commercial Production| Item | Specifications |
| Appearance | Yellowish-Orange to Orange Crystalline Powder. No visible evidence of contamination by foreign matter |
| Identification A | The IR Absorption (197K) |
| Identification B | The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the assay |
| Identification C | Meets the requirements of the flame test for Sodium (191) |
| Identification D | Part 1: A voluminous, white, crystalline precipitate is formed Part 2: The precipitate does not disappear Part 3: The precipitate dissolves completely Part 4: No precipitate is formed |
| Water Content (by K.F) | 14.5%~17.0% |
| Particle Size | 90% less than 200um |
| Assay | 90.0%~96.0% of C14H10N405 on the anhydrous basis |
| Related Substances | (HPLC, Area%) |
| Related Compound A | ≤0.15% |
| Related Compound B | ≤0.50% |
| Related Compound C | ≤0.30% |
| Residual Solvents | |
| Ethanol | ≤2000ppm |
| Methanol | ≤2000ppm |
| Acetone | ≤2000ppm |
| DMF | ≤620ppm |
| Heavy Metals | ≤10ppm |
| Shelf Life | 2 Years |
| Test Standard | United States Pharmacopoeia (USP) |
| Usage | Skeletal Muscle Relaxant. Calcium Channel Inhibitor |
Description:
Specifications:
Package & Storage:
| Chemical Name | Dantrolene Sodium Salt Hydrate |
| Synonyms | 1-[5-(4-Nitrophenyl)furfurylideneamino]hydantoin Sodium Salt Hydrate |
| CAS Number | 14663-23-1 |
| CAT Number | RF-API78 |
| Stock Status | In Stock, Production Scale Up to Hundreds of Kilograms |
| Molecular Formula | C14H11N4NaO5 |
| Molecular Weight | 338.25 |
| Solubility | Soluble in DMSO |
| Shipping Condition | Shipped Under Ambient Temperature |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
Dantrolene Sodium Salt Hydrate (CAS 14663-23-1), is a small molecule inhibitor of Ryanodine receptor antagonist and a Calcium channel inhibitor. Dantrolene Sodium Salt is a skeletal muscle relaxant, which inhibits intracellular Ca 2+release from the sarcoplasmic reticulum. Blockade of Ca2+ release from the sarcoendoplasmic reticulum, strongly related to excitation and contraction of muscles, generates a muscle relaxant effect correlated with Dantrolene. The neurotoxicity presented by pronounced glutamate activity is correlated to excessive rises in cytoplasmic Ca2+ levels, and Dantrolene is accordingly indicated as a neuroprotective agent against neurotrasmitter-induced excitotoxicity. Dantrolene, Sodium Salt is an inhibitor of RyR-1 and RyR-3.
