Chemical Properties:
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.Manufacturer with High Purity and Stable Quality Chemical Name: Caspofungin Acetate CAS: 179463-17-3 API High Quality, Commercial Production| Item | Specifications |
| Appearance | White or Almost White Powder |
| Identification IR | IR: Spectrum of Test sample should conform to that of Caspofungin Acetate Reference Standard |
| Identification HPLC | HPLC: The retention time of principle peak obtained from test solution should conform with that obtained from standard solution, as test in Assay |
| Clarity and Color | The solution should be clear and colorless |
| Specific Rotation | -102.0° ~ -108.0° |
| pH | 5.0~7.0 |
| Water | ≤10.0% |
| Related Substances I | (On Anhydrous and Acetic Acid Free Basis) |
| Impurity A | ≤0.10% |
| Impurity B | ≤0.10% |
| Impurity D | ≤0.30% |
| Impurity E | ≤0.10% |
| Unspecified Impurity F | ≤0.10% |
| Unspecified Impurity G | ≤0.10% |
| Pneumocandin B0 | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Total Impurities | ≤1.0% |
| Related Substances II | ≤0.10% |
| Residual Solvents | |
| Ethyl Acetate | ≤5000ppm |
| Ethanol | ≤5000ppm |
| Methanol | ≤5000ppm |
| Acetonitrile | ≤410ppm |
| Tetrahydrofuran | ≤720ppm |
| Acetic Acid Content | 9.0%~11.0% (Calculated on Anhydrous Basis) |
| Ethylendiamine | ≤0.10% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (as Pb) | ≤10ppm |
| Assay / Analysis Method | 97.0%~102.0% (On Anhydrous and Solvent Free Basis) |
| Test Standard | Enterprise Standard |
| Usage | Active Pharmaceutical Ingredient (API) |
Description:
Specifications:
Package & Storage:
| Chemical Name | Caspofungin Acetate |
| Synonyms | Cancidas; MK-0991 Acetate; L-743872 Acetate |
| CAS Number | 179463-17-3 |
| CAT Number | RF-API58 |
| Stock Status | In Stock, Production Scale Up to Hundreds of Kilograms |
| Molecular Formula | C52H88N10O15·2C2H4O2 |
| Molecular Weight | 1213.42 |
| Melting Point | >197℃ |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
Caspofungin Acetate (CAS: 179463-17-3) is a lipopeptide antifungal drug. Caspofungin acetate for injection was originally approved by FDA in USA, and the EMEA in Europe, in 2001. Caspofungin Acetate is a water soluble, stable, aza-substituted semisynthetic derivative of Pneumocandin B, a fermentation product of the fungus Zalerion arboricola. The lipopeptide caspofungin, inhibits the synthesis of 1,3-beta- D-glucans present only in the fungal cell wall, which leads to the specific lysis of the pathogenic cells. The compound is fungicidal rather than fungistatic, an unusual feature among antifungal agents. Caspofungin was generally more active than amphotericin B, flucytosine, fluconazole and itraconazole against Candida species.
