Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureManufacturer Supply Related Intermediates: Sodium Methanesulfinate CAS 20277-69-4 2-Aminoethyl Methyl Sulfone Hydrochloride CAS 104458-24-4 6-Iodo-4-Hydroxyquinazoline CAS 16064-08-7 5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde CAS 231278-84-5 CAS 231277-92-2 CAS 388082-77-7| Item | Specifications |
| Appearance | Yellow Crystalline Powder |
| Purity / Analysis Method | ≥99.5% (HPLC) |
| Melting Point | 240.0~242.0℃ |
| Loss on Drying | ≤1.00% |
| Moisture (K.F) | ≤1.00% |
| Single Impurity | ≤0.50% |
| Total Impurities | ≤0.50% |
| Heavy Metals (as Pb) | ≤20ppm |
| Test Standard | Enterprise Standard |
| Usage | API; For the treatment of patients with breast cancer |
Description:
Specifications:
Package & Storage:
| CAS Number | 388082-77-7 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C43H42ClFN4O10S3 |
| Molecular Weight | 925.46 |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
API (CAS: 388082-77-7) is the ditosylate salt of CAS 231277-92-2, a synthetic, orally-active quinazoline with potential antineoplastic activity. It reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types. It was launched for the treatment of advanced or metastatic HER2 (ErbB2) positive breast cancer in women who have received prior therapy. The drug was discovered and developed by GlaxoSmithKline.
