Candesartan Cilexetil CAS 145040-37-5 Purity >99.0% (HPLC) API Factory

Chemical Name: Candesartan Cilexetil 

CAS: 145040-37-5

Purity: >99.0% (HPLC) 

Appearance: White to Off-White Crystalline Powder

A Selective Angiotensin II Receptor Antagonist 

API High Quality, Commercial Production

E-Mail: alvin@ruifuchem.com

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Chemical Properties:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureRuifu Chemical Supply Candesartan Cilexetil Intermediate With High Purity Candesartan Cilexetil CAS 145040-37-5 Candesartan CAS 139481-59-7 1-Chloroethyl Cyclohexyl Carbonate CAS 99464-83-2 Candesartan Cilexetil Intermediate Eethyl Ester C6 CAS 139481-41-7 Candesartan Cilexetil Intermediate CAS 139481-44-0 Trityl Candesartan Cilexetil CAS 170791-09-0
Item Specifications
Appearance White to Off-White Crystalline Powder
Identification HPLC The retention time of the major peak in the chromatogram of the sample corresponds to that in the chromatogram obtained with the standard
Identification IR IR infrared absorption spectrum is identical to that of Candesartan Cilexetil reference standard
Clarity and Color Solution Solution in chloroform at 5% is clear and colourless
Purity / Analysis Method >99.0% (HPLC)
Melting Point 155.0~160.0℃
Loss on Drying <0.30%
Residue on Ignition <0.10%
Heavy Metals <10ppm
Arsenic (As) <1ppm
Particle Size Distribution 90% <30 μm
Organic Impurities by HPLC
Ethyl Candesartan <0.15%
Desethyl Candesartan <0.15%
N2-Ethyl Candesartan Cilexei <0.15%
Any Unknown Impurity <0.15%
Total Impurities <0.60%
Assay by Potentiometry 99.0~101.0% of C33H34N6O6, calculated on the anhydrous substance
Organic Volatile Impurity
Methano <0.30%
Ethanol  <0.50%
Diethyl Ether <0.50%
Aceton <0.50%
Dichloromethan <0.06%
Dimethylformamide <0.088%
Microbiological Contarnination 
Total Aerobic Microbial Count <1000cfu/g
Moulds & Yeasts <100cfu/g
E.Coli Absent
Salmonella Absent
Test Standard Enterprise Standard
Usage API; Antihypertensive Agent

Description:

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Chemical Name Candesartan Cilexetil
Synonyms TCV-116; 1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-Carboxylate
CAS Number 145040-37-5
CAT Number RF-PI1891
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C33H34N6O6
Molecular Weight 610.66
Brand Ruifu Chemical

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Application:

Candesartan Cilexetil (TCV-116) (CAS: 145040-37-5) is an angiotensin II receptor antagonist with IC50 of 0.26 nM, used in the treatment of hypertension. Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is administered orally as the prodrug, candesartan cilexetil, which is rapidly converted to its active metabolite, candesartan, during absorption in the gastrointestinal tract. Candesartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Candesartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.

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