Chemical Properties:
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool, dry (≤25℃) and ventilated warehouse away from incompatible substances. Protect from light and moisture.Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of N-Boc-trans-4-Hydroxy-L-Proline Methyl Ester (Boc-Hyp-OMe) (CAS: 74844-91-0) with high quality. Ruifu Chemical supplys a series of amino acids. We can provide worldwide delivery, small and bulk quantities available. Purchase Boc-Hyp-OMe , Please contact: alvin@ruifuchem.comDescription:
Package & Storage:
| Chemical Name | N-Boc-trans-4-Hydroxy-L-Proline Methyl Ester |
| Synonyms | Boc-Hyp-OMe; Boc-L-Hyp-OMe; Boc-L-trans-4-Hydroxyproline Methyl Ester; Boc-L-Hydroxyproline Methyl Ester; N-(tert-Butoxycarbonyl)-trans-4-Hydroxy-L-Proline Methyl Ester; 1-tert-Butyl 2-Methyl (2S,4R)-4-Hydroxypyrrolidine-1,2-Dicarboxylate; (2S,4R)-4-Hydroxypyrrolidine-1,2-Dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester; Boc-(2S,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acid Methyl Ester |
| Stock Status | In Stock |
| CAS Number | 74844-91-0 |
| Molecular Formula | C11H19NO5 |
| Molecular Weight | 245.28 g/mol |
| Melting Point | 92.0~96.0℃ |
| Boiling Point | 132℃/0.05 mmHg |
| Density | 1.216 |
| Solubility | Soluble in Chloroform, Dichloromethane and Ethyl Acetate |
| Storage Temp. | Cool & Dry Place (≤25℃) |
| COA & MSDS | Available |
| Category | Unnatural Amino Acids |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White Powder | White Powder |
| Melting Point | 92.0~96.0℃ | 92.0~96.0℃ |
| Specific Rotation [α]20/D | -63.0° to -67.0° (C=1, CHCl3) | -63.9° |
| Loss on Drying | <0.50% | 0.23% |
| Purity / Analysis Method | >99.0% (HPLC) | 99.18% |
| Clarity of Solution | 0.3 gram in 2ml DMF Clear Solution | Complies |
| Mass Spectrum | In Accordance With the Standard | Complies |
| NMR Spectrum | In Accordance With the Standard | Complies |
| Conclusion | This Product by Inspection Accords with the Enterprise Standard | |
| Main Uses | Peptide Synthesis; Pharmaceutical Intermediates； etc. | |
Application:
N-Boc-trans-4-Hydroxy-L-Proline Methyl Ester (Boc-Hyp-OMe) (CAS: 74844-91-0), amino acids and derivatives, peptide synthesis, used as amino acid protective monomer, organic synthesis intermediate, pharmaceutical intermediates, biochemical reagents, chemical reagents. Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.74844-91-0 - Risk and Safety:
Hazard Symbols Xn - Harmful Risk Codes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. Safety Description S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. WGK Germany 3 HS Code 2922491990 Hazard Class IRRITANT