Chemical Properties:
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry (0~8℃) warehouse away from incompatible substances. Protect from light and moisture.Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of trans-N-Boc-4-Hydroxy-L-Proline (Boc-Hyp-OH) (CAS: 13726-69-7) with high quality. Ruifu Chemical supplys a series of amino acids and derivatives. We can provide worldwide delivery, small and bulk quantities available. Purchase Boc-Hyp-OH, Please contact: alvin@ruifuchem.com| Safety Statements | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. | ||
| WGK Germany | 3 | HS Code | 2922491990 |
| Hazard Class | Irritant | ||
Description:
Safety Information:
Package & Storage:
| Chemical Name | trans-N-Boc-4-Hydroxy-L-Proline |
| Synonyms | Boc-Hyp-OH; Boc-L-Hyp-OH; trans-N-(tert-Butoxycarbonyl)-4-Hydroxy-L-Proline; Boc-L-Hydroxyproline; N-Boc-trans-4-Hydroxy-L-Proline; Boc-L-trans-4-Hydroxyproline; Boc-(2S,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acid |
| Stock Status | In Stock, Production Capacity To Tons |
| CAS Number | 13726-69-7 |
| Molecular Formula | C10H17NO5 |
| Molecular Weight | 231.25 g/mol |
| Melting Point | 115.0~125.0℃(lit.) |
| Density | 1.312±0.06 g/cm3 |
| Water Solubility | Very Faint Turbidity |
| Storage Temp. | Cool & Dry Place (0~8℃) |
| COA & MSDS | Available |
| Category | Unusual Amino Acids |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White Powder | White Powder |
| Boc-Hyp-OH Purity | >99.0% (HPLC) | 99.37% |
| TLC | ≥98.0% | >98.0% |
| Element Analysis (C、H、N) | ≤5.0% | <5.0% |
| Melting Point | 115.0~125.0℃ | 122.2~122.6℃ |
| Specific Rotation [α]20/D | -50.0° to -53.0° (C=1 in DMF) | -52.5° |
| Water Content (K.F.) | <0.50% | 0.249% |
| Loss on Drying | <0.50% (50℃, 2h) | 0.28% |
| Clarity of Solution | 0.3 gram in 2ml DMF Clear Solution | Complies |
| Mass Spectrum | In Accordance With the Standard | Complies |
| NMR Spectrum | In Accordance With the Standard | Complies |
| Conclusion | This Product by Inspection Accords with the Enterprise Standard | |
Application:
trans-N-Boc-4-Hydroxy-L-Proline (Boc-Hyp-OH) (CAS: 13726-69-7), unusual amino acids, used in peptide synthesis, organic synthesis intermediates, pharmaceutical intermediates, biochemical reagents, chemical reagents. Boc-Hyp-OH is used in the preparation of hydroxyproline derivatives. Boc-Hyp-OH is an intermediate in the synthesis of Fosinopril-d5 Sodium Salt, the labeled analogue of Fosinopril Sodium Salt, a phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Antihypertensive. Background: Proline is one of the important amino acids for the synthesis of human protein, an important raw material for amino acid infusion, and a major intermediate for the synthesis of captopril, enalapril and other first-line antihypertensive drugs. it has been widely used in food and medicine industries. It can be used for amino acid injections, compound amino acid infusions, food additives, nutritional supplements, etc.; it can be used for biochemical research, and it can be used for malnutrition, protein deficiency, gastrointestinal diseases, scalds and postoperative protein supplements in medicine, etc.; It can be used for nutritional supplements, flavors, amino-carbonyl reactions occur in co-heating with sugar, which can generate special fragrance substances, which can be used as spices according to my country's GB2760-86 regulations; it can be used for amino acid drugs. It is one of the raw materials for compound amino acid infusion. It is used for malnutrition, protein deficiency, severe gastrointestinal diseases, burns and protein supplementation after surgical operations; it can be used for pharmaceutical raw materials and food additives. Preparation 1. add 18.1g L-Proline and 10ml water to the reaction bottle and stir. Add 16g of 0.1mol/L lye of sodium hydroxide to alkaline. Add 8g of (Boc)2O for 1 hour, 8g of (Boc)2O for 1 hour, and finally 9g of (Boc)2O for 3 hours. 2. Use petroleum ether 1ml/time to extract impurities three times. After 3mol/L hydrochloric acid adjusts PH = 3, ethyl acetate 0.5L/time is used to extract the product three times. Combine ester layers and wash with brine to neutral. Add 15 grams of anhydrous sodium sulfate and dry for 6 hours. 3. Filter, concentrate and dry the filtrate under reduced pressure, add 50ml petroleum ether, stir and crystallize. Centrifuge out the product and dry it. The product 26.3g is obtained. The yield is 93.57%.