Chemical Properties:
Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool, dry (≤25℃) and ventilated warehouse away from incompatible substances. Protect from light and moisture.Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of N-Boc-D-Tryptophan (Boc-D-Trp-OH) (CAS: 5241-64-5). Ruifu Chemical supplys a series of amino acids and derivatives. We can provide worldwide delivery, small and bulk quantities available. Purchase Boc-D-Trp-OH, Please contact: alvin@ruifuchem.com| Safety Statements | 24/25 - Avoid contact with skin and eyes. | ||
| WGK Germany | 3 | HS Code | 2922491990 |
Description:
Safety Information:
Package & Storage:
| Chemical Name | N-Boc-D-Tryptophan |
| Synonyms | Boc-D-Trp-OH; N-Boc-D-Trp-OH; Boc-D-Tryptophan; Nα-Boc-D-Tryptophan; N-(tert-Butoxycarbonyl)-D-Tryptophan; N(alpha)-Boc-D-Tryptophan; N(alpha)-tert-Butoxycarbonyl-D-Tryptophan |
| Stock Status | In Stock |
| CAS Number | 5241-64-5 |
| Molecular Formula | C16H20N2O4 |
| Molecular Weight | 304.35 g/mol |
| Melting Point | 130.0~136.0℃ |
| Density | 1.262 |
| Sensitive | Light Sensitive, Air Sensitive |
| Solubility in Methanol | Almost Transparency |
| Storage Temp. | Cool & Dry Place (≤25℃) |
| COA & MSDS | Available |
| Category | Boc-Amino Acids |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White to Off-White Powder | White Powder |
| Melting Point | 130.0~136.0℃ | 130.2~133.0℃ |
| Specific Rotation [α]20/D | +20° ± 2.0° (C=2 in AcOH) | +18.5° |
| Loss on Drying | <0.50% | 0.15% |
| Residue on Ignition | <0.10% | 0.08% |
| Purity / Analysis Method | >98.5% (HPLC) | 99.29% |
| Optical Purity | <0.50% L-Enantiomer | 0.0365% |
| 300 MHz NMR Spectrum 1H | Conforms to Structure | Complies |
| TLC Analysis | One Spot | Complies |
| Infrared Spectrum | Conforms to Structure | Complies |
| Conclusion | This Product by Inspection Accords with the Enterprise Standard | |
| Main Uses | Boc-Amino Acids; Peptide Synthesis; Pharmaceutical Intermediates | |
Application:
N-Boc-D-Tryptophan (Boc-D-Trp-OH) (CAS: 5241-64-5), amino acids and derivatives, peptide synthesis, organic synthesis intermediate, pharmaceutical intermediates, biochemical reagents. Boc-D-Trp-OH is an N-Boc-protected form of D-Tryptophan. D-Tryptophan is an unnatural isomer of L-Tryptophan and is classified as an essential amino acid. D-Tryptophan has been synthesized as part of some potent Oxytocin antagonists that treat preterm labour. Brief introduction: Boc-D-Tryptophan can be used as an intermediate in pharmaceutical synthesis, such as tadalafil (tadalafil). tadalafil is developed by Lilly pharmaceutical company in the United States. it relies on PDE-5 to improve the vasodilation effect of NO by inhibiting the decomposition of cGMP, so that ED patients can regain the ability of penile erection, and is mainly used to treat male erectile dysfunction. It was listed in Europe in February 2003 and in the United States in December 2003. It is the third new drug approved by FDA for ED. Preparation: compound D-Tryptophan (50g, 0.245mol) is weighed in a three-mouth bottle, mechanically stirred, 500ml of water and Triethylamine (74g, 0.731mol),(Boc)2O (56g, 0.257mol) are added. The reaction was stirred at 45 degrees Celsius for 12 hours. At the end of the reaction, 0.1% phosphoric acid solution is added dropwise, a large amount of solid is generated, the PH value is adjusted to 7, and then post-treatment is carried out. Filtration, the resulting solid is dissolved with ethyl acetate, the resulting solution is washed once with water, anhydrous sodium sulfate is dried, and after filtration, the organic phase is spin-dried to prepare the compound Boc-D-Tryptophan in an amount of 70.9g (0.233mol), and the yield of Boc-D-Tryptophan is calculated to be 95.1%.