Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.High Purity, Commercial Production Olaparib and Related Intermediates: Olaparib CAS 763113-22-0 2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid CAS 763114-26-7 1-(Cyclopropylcarbonyl)piperazine Hydrochloride CAS 1021298-67-8 3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9| Item | Specifications |
| Appearance | White or Almost White Powder |
| Purity | ≥98.0% |
| Moisture (K.F) | ≤0.50% |
| Total Impurities | ≤2.0% |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Olaparib (CAS: 763113-22-0) PARP-Inhibitor |
Description:
Specifications:
Package & Storage:
| Chemical Name | 3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid |
| Synonyms | Dimethyl 3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonate |
| CAS Number | 61260-15-9 |
| CAT Number | RF-PI453 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C10H11O5P |
| Molecular Weight | 242.17 |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid (CAS: 61260-15-9), intermediate of Olaparib (CAS: 763113-22-0). Olaparib is a kind of novel poly ADP-ribose polymerase (PARP) inhibitors, including PARP1, PARP2, and PARP3. PARP mediates a DNA-repair mechanism which plays a important role in DNA damage repair and apoptosis, so olaparib specifically targets on the DNA repair mechanism of the targeting cell DNA repair and take effects by attacking the critical vulnerabilities of cancer cells carrying mutations in BRCA1 and BRCA2. Owing to this mechanism, it can be used for the maintenance therapy of patients of severe recurrent ovarian cancer who has breast cancer susceptibility gene (BRCA) mutation as well as being sensitive to platinum drug.
