Chemical Properties:
Package: Fluorinated Bottle, 25kg/Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureLeading Manufacturer and Supplier, Intermediates of Ramelteon Ramelteon (TAK-375) CAS 196597-26-9 2,3-Dihydrobenzofuran CAS 496-16-2 1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-one CAS 196597-78-1 Ramelteon Acrylonitrile CAS 196597-79-2 Despropionyl Ramelteon Hydrochloride CAS 196597-80-5 2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6 Please contact: alvin@ruifuchem.com| Item | Specifications |
| Appearance | Clear Colorless or Yellowish Liquid |
| Purity / Analysis Method | >99.0% (GC) |
| Water (by Karl Fischer) | <0.50% |
| Density (20℃) | 1.065~1.085 |
| Refractive Index n20/D | 1.547~1.551 |
| Single Impurity | <0.50% |
| Total Impurities | <1.00% |
| Proton NMR Spectrum | Conforms to Structure |
| Test Standard | Enterprise Standard |
| Usage | Pharmaceutical Intermediate of Ramelteon (CAS: 196597-26-9) |
Description:
Specifications:
Package & Storage:
| Chemical Name | 2,3-Dihydrobenzofuran |
| Synonyms | Coumaran; 2,3-Dihydro-2,3-Benzofuran; 2,3-Dihydrobenzo[b]furan; 2,3-Dihydro-1-Benzofuran |
| CAS Number | 496-16-2 |
| CAT Number | RF2884 |
| Stock Status | In Stock, Production Capacity 20 Tons per Month |
| Molecular Formula | C8H8O |
| Molecular Weight | 120.15 |
| Melting Point | -21℃ |
| Boiling Point | 188.0~189.0℃ (lit.) |
| Flash Point | 66℃ |
| Solubility | Alcohol: Soluble |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29329995 |
| Storage Temp. | Sealed in Dry, Room Temperature |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Application:
2,3-Dihydrobenzofuran (CAS: 496-16-2) is widely used in the synthesis of tricyclic compounds and is also an intermediate raw material for the synthesis of some important drugs. 2,3-Dihydrobenzofuran can be used as an intermediate of Ramelteon (CAS: 196597-26-9). Ramelteon, marketed as Rozerem by Takeda Pharmaceuticals North America, is a sleep agent that selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN), instead of binding to GABAA receptors, such as with drugs like zolpidem. It however does not appear to speed the onset of sleep or the amount of sleep a person gets. It is approved by the U.S. Food and Drug Administration (FDA) for long-term use. Ramelteon does not show any appreciable binding to GABAA receptors, which are associated with anxiolytic, myorelaxant, and amnesic effects. Unlike most treatments of insomnia that target the GABA (g-aminobutyric acid) receptor complex, ramelteon is an agonist of the melatonin receptor. In particular, it has high selectivity for the MT1 and MT2 subtypes, which have been implicated in the maintenance of circadian rhythms, over the MT3 receptor responsible for other melatonin functions. 2,3-Dihydrobenzofuran is also used in the synthesis of antitumor agents benzofuran sulfonylureas, HIV protease inhibitor amino acid hydroxyethylenesulfonyl, matrix metalloproteinase inhibitor aryl sulfinyl isoxime hydroxamic acid, etc.Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available