Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Drum, or according to customer's requirement. Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture.Ruifu Chemical is the leading manufacturer of 1-Boc-3-Hydroxypiperidine (CAS: 85275-45-2) with high quality, can be used as an intermediate of Ibrutinib (CAS: 936563-96-1). Ruifu Chemical can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase 1-Boc-3-Hydroxypiperidine, Please contact: alvin@ruifuchem.com| Item | Specifications | Specifications |
| Appearance | White to Off-White Crystals | Conforms |
| Melting Point | 65.0~70.0℃ | 65.0~67.0℃ |
| Purity | ≥98.0% (GC) | 98.6% |
| Purity | ≥98.0% (with Total Nitrogen) | Conforms |
| Loss on Drying | ≤0.50% | 0.26% |
| Residue on Ignition | ≤0.20% | 0.08% |
| Infrared Spectrum | Conforms to Structure | Conforms |
| 1 H NMR Spectrum | Conforms to Structure | Conforms |
| Test Standard | Enterprise Standard | Conforms |
| Usage | Pharmaceutical Intermediates; Intermediate of Ibrutinib (CAS: 936563-96-1) | |
Description:
Specifications:
Package & Storage:
| Chemical Name | 1-Boc-3-Hydroxypiperidine |
| Synonyms | N-Boc-3-Hydroxypiperidine;1-(tert-Butoxycarbonyl)-3-Hydroxypiperidine; 1-Boc-3-Piperidinol; N-Boc-3-Piperidinol; N-(tert-Butoxycarbonyl)-3-Piperidinol; tert-Butyl 3-Hydroxy-1-Piperidinecarboxylate; Boc-3-Hydroxypiperidine |
| CAS Number | 85275-45-2 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C10H19NO3 |
| Molecular Weight | 201.26 |
| Melting Point | 65.0~70.0℃ |
| Density | 1.107±0.06 g/cm3 |
| Shipping Condition | Shipped Under Ambient Temperature |
| COA & MSDS | Available |
| Origin | Shanghai, China |
| Category | Pharmaceutical Intermediates |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
85275-45-2 - Risk and Safety:
Hazard Symbols Xi - Irritant Risk Codes R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. WGK Germany 3 Hazard Class IRRITANT
85275-45-2 - Application:
1-Boc-3-Hydroxypiperidine (CAS: 85275-45-2), widely used in organic synthesis, used as a pharmaceutical intermediate in the synthesis of Active Pharmaceutical Ingredient (API) synthesis. 1-Boc-3-Hydroxypiperidine can be used as an Intermediate of Ibrutinib (CAS: 936563-96-1). Ibrutinib is a kind of Bruton tyrosine kinase (BTK) inhibitor, it could be used for the treatment of chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). Food and Drug Administration (FDA) of USA has speed up approval of Pharmacyclics Corporation and Johnson & Johnson's Imbruvica (generic name: Ibrutinib) came to market to the cure a kind of rarely aggressive leukemia-mantle cell lymphoma (MCL) in 13th November, 2013. Ibrutinib is a new kind of oral Bruton tyrosine kinase (BTK) inhibitor, it was awarded by FDA be a breakthrough drugs in February of 2013, and approved the MCL and CLL treatments in 13th November, 2013 and 12th February, 2014 respectively.Intermediates of Ibrutinib: