The compound 2,4-Dinitrophenol (CAS 51-28-5) is a highly toxic organic chemical that has found limited use as a weight-loss supplement. Often referred to as DNP, this drug was initially employed in the manufacture of dyes and explosives, but its ability to disrupt the proton gradient that powers cellular metabolism made it an effective slimming aid. DNP works by uncoupling the oxidative phosphorylation that converts food into energy, thus promoting thermogenesis and encouraging the body to burn fat stores. Although it does promote weight loss, its lethality and adverse effects have largely led to its restriction and even banning in several countries, including the US and the UK. Despite its obvious dangers, 2,4-Dinitrophenol continues to be sold illicitly as a weight loss drug. Its usage can lead to hyperthermia, tachycardia, arrhythmia, muscle rigidity, and ultimately death. Furthermore, it can cause permanent damage to the liver, kidneys, and central nervous system. Anyone considering taking DNP should be aware of the risks and negative consequences associated with its use, and should consult a healthcare professional before doing so. In general, it is highly recommended that this drug be avoided altogether, and that safer and more effective weight loss methods be adopted instead.

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